Mouse Anti-GSS Recombinant Antibody (CBLG1-1935) (CBMAB-G5343-LY)

Name: Mouse Anti-GSS Recombinant Antibody (CBLG1-1935)
SKU: CBMAB-G5343-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLG1-1935

Application

Immunogen

Glutathione Synthetase

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% glycerol

Preservative

0.02% NaN3

Concentration

0.5 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

glutathione synthetase

Introduction

Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008]

Entrez Gene ID

2937

UniProt ID

P48637

Alternative Names

Glutathione Synthetase; Glutathione Synthase; GSH Synthetase; EC 6.3.2.3; GSH-S; HEL-S-64p; HEL-S-88n; GSHS;

Function

Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686).

Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:10369661).

Biological Process

Cellular amino acid metabolic process Source: ProtInc
Nervous system development Source: ProtInc
Response to cadmium ion Source: Ensembl
Response to oxidative stress Source: ProtInc

Cellular Location

Cytosol; Extracellular exosome

Involvement in disease

Glutathione synthetase deficiency (GSS deficiency):
Severe form characterized by an increased rate of hemolysis and defective function of the central nervous system.
Glutathione synthetase deficiency of erythrocytes (GLUSYNDE):
Mild form causing hemolytic anemia.

Chen, C., Gong, W., Tian, J., Gao, X., Qin, X., Du, G., & Zhou, Y. (2023). Radix Paeoniae Alba attenuates Radix Bupleuri-induced hepatotoxicity by modulating gut microbiota to alleviate the inhibition of saikosaponins on glutathione synthetase. Journal of Pharmaceutical Analysis.

Wu, Y., Wang, D., Lou, Y., Liu, X., Huang, P., Jin, M., & Huang, G. (2022). Regulatory mechanism of α-hederin upon cisplatin sensibility in NSCLC at safe dose by destroying GSS/GSH/GPX2 axis–mediated glutathione oxidation-reduction system. Biomedicine & Pharmacotherapy, 150, 112927.

Chen, P., Wang, L., Sun, S., Zhou, Q., Zeng, Z., Hu, M., ... & Du, H. (2020). High-throughput screening suggests glutathione synthetase as an anti-tumor target of polydatin using human proteome chip. International Journal of Biological Macromolecules, 161, 1230-1239.

Zheng, C., Zhang, L., Chen, M., Zhao, X. Q., Duan, Y., Meng, Y., ... & Shen, R. F. (2018). Effects of cadmium exposure on expression of glutathione synthetase system genes in Acidithiobacillus ferrooxidans. Extremophiles, 22, 895-902.

Xia, H., Ye, J., Wang, L., Zhu, J., & He, Z. (2018). A case of severe glutathione synthetase deficiency with novel GSS mutations. Brazilian Journal of Medical and Biological Research, 51.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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