Sign in or Register   Sign in or Register
  |  

Mouse Anti-GSTA1 Recombinant Antibody (CBFYH-0517) (CBMAB-H1393-FY)

This product is mouse antibody that recognizes GSTA1. The antibody CBFYH-0517 can be used for immunoassay techniques such as: ELISA, ICC, IHC, WB.
See all GSTA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0517
Application
ELISA, ICC, IHC, WB

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Glutathione S-Transferase Alpha 1
Introduction
This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
2938
UniProt ID
P08263
Alternative Names
Glutathione S-Transferase Alpha 1; Glutathione S-Transferase A1; GST Class-Alpha Member 1; GST HA Subunit 1; GST-Epsilon; EC 2.5.1.18; GSTA1-1; GTH1
Function
Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911).

It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686).

Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487).
Biological Process
Epithelial cell differentiation Source: UniProtKB
Glutathione derivative biosynthetic process Source: UniProtKB
Glutathione metabolic process Source: UniProtKB
Linoleic acid metabolic process Source: BHF-UCL
Prostaglandin metabolic process Source: UniProtKB
Xenobiotic metabolic process Source: GO_Central
Cellular Location
Cytoplasm

Nguyen, A. H., Biswas, M., Puangpetch, A., Prommas, S., Pakakasama, S., Anurathapan, U., ... & Sukasem, C. (2022). Effect of GSTA1 Variants on Busulfan-Based Conditioning Regimen Prior to Allogenic Hematopoietic Stem-Cell Transplantation in Pediatric Asians. Pharmaceutics, 14(2), 401.

Chang, Y., He, J., Ma, B., Ishfaq, M., Wang, J., Zhang, R., ... & Liu, F. (2021). Prevention of acetaminophen-induced hepatocyte injury: JNK inhibition and GSTA1 involvement. Molecular & Cellular Toxicology, 17, 161-168.

Mlakar, V., Curtis, P. H. D., Armengol, M., Ythier, V., Dupanloup, I., Hassine, K. B., ... & Ansari, M. (2021). The analysis of GSTA1 promoter genetic and functional diversity of human populations. Scientific reports, 11(1), 1-12.

Alqarni, M. H., Foudah, A. I., Muharram, M. M., & Labrou, N. E. (2021). The Interaction of Human Glutathione Transferase GSTA1-1 with Reactive Dyes. Molecules, 26(8), 2399.

Zhang, Y., Ma, B., Hao, S., Wang, J., Zhang, R., Ishfaq, M., ... & Liu, F. (2021). Drug‐induced liver injury: Oltipraz and C2‐ceramide intervene HNF‐1α/GSTA1 expression via JNK signaling pathway. Journal of Applied Toxicology, 41(12), 2011-2020.

Kumar, M., Martin, A., Nirgude, S., Chaudhary, B., Mondal, S., & Sarkar, A. (2020). Quinacrine inhibits GSTA1 activity and induces apoptosis through G1/S arrest and generation of ROS in human non-small cell lung cancer cell lines. Oncotarget, 11(18), 1603.

Sun, Y., Huang, J., Hao, C., Li, Z., Liang, W., Zhang, W., ... & Hu, J. (2020). Population pharmacokinetic analysis of intravenous busulfan: GSTA1 genotype is not a predictive factor of initial dose in Chinese adult patients undergoing hematopoietic stem cell transplantation. Cancer Chemotherapy and Pharmacology, 85, 293-308.

Michaud, V., Tran, M., Pronovost, B., Bouchard, P., Bilodeau, S., Alain, K., ... & Turgeon, J. (2019). Impact of GSTA1 polymorphisms on busulfan oral clearance in adult patients undergoing hematopoietic stem cell transplantation. Pharmaceutics, 11(9), 440.

Li, X., Wang, B., Tang, L., Zhang, Y., Chen, L., Gu, L., ... & Zhang, X. (2018). GSTA1 expression is correlated with aldosterone level in KCNJ5-mutated adrenal aldosterone-producing adenoma. The Journal of Clinical Endocrinology & Metabolism, 103(3), 813-823.

Nava, T., Kassir, N., Rezgui, M. A., Uppugunduri, C. R. S., Huezo‐Diaz Curtis, P., Duval, M., ... & Bittencourt, H. (2018). Incorporation of GSTA1 genetic variations into a population pharmacokinetic model for IV busulfan in paediatric hematopoietic stem cell transplantation. British journal of clinical pharmacology, 84(7), 1494-1504.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-GSTA1 Recombinant Antibody (CBFYH-0517)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare