GSTA1
This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Full Name
Glutathione S-Transferase Alpha 1
Function
Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911).
It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686).
Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487).
It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686).
Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487).
Biological Process
Epithelial cell differentiation Source: UniProtKB
Glutathione derivative biosynthetic process Source: UniProtKB
Glutathione metabolic process Source: UniProtKB
Linoleic acid metabolic process Source: BHF-UCL
Prostaglandin metabolic process Source: UniProtKB
Xenobiotic metabolic process Source: GO_Central
Glutathione derivative biosynthetic process Source: UniProtKB
Glutathione metabolic process Source: UniProtKB
Linoleic acid metabolic process Source: BHF-UCL
Prostaglandin metabolic process Source: UniProtKB
Xenobiotic metabolic process Source: GO_Central
Cellular Location
Cytoplasm
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Anti-GSTA1 antibodies
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CompareTarget: GSTA1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP868
Application*: ICC, IHC, IP, WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-1999
Application*: WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-1998
Application*: E, WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBLG1-1995
Application*: WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1993
Application*: E
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1992
Application*: E, IP, WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: S. japonicum
Clone: CBLG1-1991
Application*: E
Target: GSTA1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Mouse
Clone: CBLG1-1989
Application*: WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1986
Application*: E, P, WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Mouse
Clone: CBLG1-1985
Application*: WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG
Specificity: S. japonicum
Clone: CBLG1-1984
Application*: WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: S. japonicum
Clone: CBLG1-1981
Application*: E
Target: GSTA1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBLG1-1980
Application*: WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1979
Application*: E, WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1978
Application*: IC, C/P, E (IA), WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1977
Application*: WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3G10
Application*: IF, IH, IP, WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 38H11
Application*: P
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2-2
Application*: WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 13j40
Application*: E, IH, WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG
Specificity: S. japonicum
Clone: CBLG1-261
Application*: IP, WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-260
Application*: E, WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-259
Application*: E, IH, WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Mouse
Clone: 286CT8.1.5
Application*: WB
Target: GSTA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-0518
Application*: E, WB, IH
Target: GSTA1
Host: Mouse
Specificity: Human
Clone: CBFYH-0517
Application*: E, IC, IH, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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