Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-1978) (CBMAB-G5432-LY)

Name: Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-1978)
SKU: CBMAB-G5432-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLG1-1978

Application

ICC, IHC-F/P, ELISA (EIA), WB

Immunogen

The antibody is a mouse monoclonal antibody raised against GSTa1. It has been selected for its ability to recognize GSTa1 in immunohistochemical staining andwestern blotting

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% glycerol

Preservative

0.02% NaN3

Concentration

0.5 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Glutathione S-Transferase Alpha 1

Introduction

This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Entrez Gene ID

2938

UniProt ID

P08263

Alternative Names

Glutathione S-Transferase Alpha 1; Glutathione S-Transferase A1; GST Class-Alpha Member 1; GST HA Subunit 1; GST-Epsilon; EC 2.5.1.18; GSTA1-1; GTH1;

Function

Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911).

It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686).

Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487).

Biological Process

Epithelial cell differentiation Source: UniProtKB
Glutathione derivative biosynthetic process Source: UniProtKB
Glutathione metabolic process Source: UniProtKB
Linoleic acid metabolic process Source: BHF-UCL
Prostaglandin metabolic process Source: UniProtKB
Xenobiotic metabolic process Source: GO_Central

Cellular Location

Cytoplasm

Nguyen, A. H., Biswas, M., Puangpetch, A., Prommas, S., Pakakasama, S., Anurathapan, U., ... & Sukasem, C. (2022). Effect of GSTA1 Variants on Busulfan-Based Conditioning Regimen Prior to Allogenic Hematopoietic Stem-Cell Transplantation in Pediatric Asians. Pharmaceutics, 14(2), 401.

Chang, Y., He, J., Ma, B., Ishfaq, M., Wang, J., Zhang, R., ... & Liu, F. (2021). Prevention of acetaminophen-induced hepatocyte injury: JNK inhibition and GSTA1 involvement. Molecular & Cellular Toxicology, 17, 161-168.

Mlakar, V., Curtis, P. H. D., Armengol, M., Ythier, V., Dupanloup, I., Hassine, K. B., ... & Ansari, M. (2021). The analysis of GSTA1 promoter genetic and functional diversity of human populations. Scientific reports, 11(1), 1-12.

Alqarni, M. H., Foudah, A. I., Muharram, M. M., & Labrou, N. E. (2021). The Interaction of Human Glutathione Transferase GSTA1-1 with Reactive Dyes. Molecules, 26(8), 2399.

Zhang, Y., Ma, B., Hao, S., Wang, J., Zhang, R., Ishfaq, M., ... & Liu, F. (2021). Drug‐induced liver injury: Oltipraz and C2‐ceramide intervene HNF‐1α/GSTA1 expression via JNK signaling pathway. Journal of Applied Toxicology, 41(12), 2011-2020.

Kumar, M., Martin, A., Nirgude, S., Chaudhary, B., Mondal, S., & Sarkar, A. (2020). Quinacrine inhibits GSTA1 activity and induces apoptosis through G1/S arrest and generation of ROS in human non-small cell lung cancer cell lines. Oncotarget, 11(18), 1603.

Sun, Y., Huang, J., Hao, C., Li, Z., Liang, W., Zhang, W., ... & Hu, J. (2020). Population pharmacokinetic analysis of intravenous busulfan: GSTA1 genotype is not a predictive factor of initial dose in Chinese adult patients undergoing hematopoietic stem cell transplantation. Cancer Chemotherapy and Pharmacology, 85, 293-308.

Michaud, V., Tran, M., Pronovost, B., Bouchard, P., Bilodeau, S., Alain, K., ... & Turgeon, J. (2019). Impact of GSTA1 polymorphisms on busulfan oral clearance in adult patients undergoing hematopoietic stem cell transplantation. Pharmaceutics, 11(9), 440.

Li, X., Wang, B., Tang, L., Zhang, Y., Chen, L., Gu, L., ... & Zhang, X. (2018). GSTA1 expression is correlated with aldosterone level in KCNJ5-mutated adrenal aldosterone-producing adenoma. The Journal of Clinical Endocrinology & Metabolism, 103(3), 813-823.

Nava, T., Kassir, N., Rezgui, M. A., Uppugunduri, C. R. S., Huezo‐Diaz Curtis, P., Duval, M., ... & Bittencourt, H. (2018). Incorporation of GSTA1 genetic variations into a population pharmacokinetic model for IV busulfan in paediatric hematopoietic stem cell transplantation. British journal of clinical pharmacology, 84(7), 1494-1504.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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