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Mouse Anti-GSTT1 (AA 1-241) Recombinant Antibody (CBFYH-0524) (CBMAB-H1402-FY)

This product is mouse antibody that recognizes GSTT1. The antibody CBFYH-0524 can be used for immunoassay techniques such as: ELISA, WB.
See all GSTT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0524
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant protein with GST Tag
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-241

Target

Full Name
glutathione S-transferase theta 1
Introduction
The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants.
Entrez Gene ID
2952
UniProt ID
P30711
Alternative Names
Glutathione S-Transferase Theta 1; EC 2.5.1.18; Glutathione Transferase T1-1; GST Class-Theta-1
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.
Biological Process
Glutathione metabolic process Source: UniProtKB
Cellular Location
Cytoplasm

Nakanishi, G., Bertagnolli, L. S., Pita-Oliveira, M., Scudeler, M. M., Torres-Loureiro, S., Almeida-Dantas, T., ... & Rodrigues-Soares, F. (2022). GSTM1 and GSTT1 polymorphisms in healthy volunteers–a worldwide systematic review. Drug Metabolism Reviews, 54(1), 37-45.

Abbas, M., Verma, S., Verma, S., Siddiqui, S., Khan, F. H., Raza, S. T., ... & Mahdi, F. (2021). Association of GSTM1 and GSTT1 gene polymorphisms with COVID‐19 susceptibility and its outcome. Journal of medical virology, 93(9), 5446-5451.

Saadat, M. (2020). An evidence for correlation between the glutathione S-transferase T1 (GSTT1) polymorphism and outcome of COVID-19. Clinica chimica acta; international journal of clinical chemistry, 508, 213.

Chanhom, N., Udomsinprasert, W., Mahasirimongkol, S., Wattanapokayakit, S., & Jittikoon, J. (2020). GSTM1 and GSTT1 genetic polymorphisms and their association with antituberculosis drug‑induced liver injury. Biomedical Reports, 12(4), 153-162.

Song, L., Yang, C., & He, X. F. (2020). Individual and combined effects of GSTM1 and GSTT1 polymorphisms on colorectal cancer risk: an updated meta-analysis. Bioscience Reports, 40(8).

Li, S., Xue, F., Zheng, Y., Yang, P., Lin, S., Deng, Y., ... & Chen, S. (2019). GSTM1 and GSTT1 null genotype increase the risk of hepatocellular carcinoma: evidence based on 46 studies. Cancer cell international, 19(1), 1-12.

Klusek, J., Nasierowska-Guttmejer, A., Kowalik, A., Wawrzycka, I., Lewitowicz, P., Chrapek, M., & Głuszek, S. (2018). GSTM1, GSTT1, and GSTP1 polymorphisms and colorectal cancer risk in Polish nonsmokers. Oncotarget, 9(30), 21224.

Benabdelkrim, M., Djeffal, O., & Berredjem, H. (2018). GSTM1 and GSTT1 polymorphisms and susceptibility to prostate cancer: a case-control study of the Algerian population. Asian Pacific journal of cancer prevention: APJCP, 19(10), 2853.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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