Mouse Anti-GTF2B Recombinant Antibody (CBLG1-2102) (CBMAB-G5673-LY)

Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8504927, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312).
Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352).
Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171).
Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:9420329, PubMed:16230532, PubMed:7675079, PubMed:10619841).
Modulates transcription start site selection (PubMed:10318856).
Exhibits also autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194).
Positive regulation of core promoter binding Source: GO_Central
Protein acetylation Source: UniProtKB
RNA polymerase II core complex assembly Source: UniProtKB
RNA polymerase II preinitiation complex assembly Source: UniProtKB
Transcriptional start site selection at RNA polymerase II promoter Source: UniProtKB
Transcription by RNA polymerase II Source: ARUK-UCL
Transcription initiation from RNA polymerase II promoter Source: UniProtKB
Viral transcription Source: GO_Central
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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