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Mouse Anti-GTF2H5 Recombinant Antibody (CBLG1-2124) (CBMAB-G5720-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Fruit fly, Cattle, Pig, Rat
Clone
CBLG1-2124
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Specificity
Human, Mouse, Fruit fly, Cattle, Pig, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
general transcription factor IIH, polypeptide 5
Entrez Gene ID
Human404672
Mouse66467
Rat502227
Cattle518046
Pig100739493
UniProt ID
HumanQ6ZYL4
MouseQ8K2X8
RatD3ZEI7
CattleQ2T9Z5
PigF2Z5A9
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell.
Biological Process
Cellular response to gamma radiation Source: Ensembl
Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: Ensembl
Nucleotide-excision repair Source: MGI
Nucleotide-excision repair, preincision complex assembly Source: GO_Central
Phosphorylation of RNA polymerase II C-terminal domain Source: GO_Central
Transcription by RNA polymerase II Source: GO_Central
Transcription elongation from RNA polymerase I promoter Source: Ensembl
Transcription initiation from RNA polymerase II promoter Source: InterPro
Cellular Location
Nucleus; Cytoplasm
Involvement in disease
Trichothiodystrophy 3, photosensitive (TTD3):
A form of trichothiodystrophy, an autosomal recessive disease characterized by sulfur-deficient brittle hair and multisystem variable abnormalities. The spectrum of clinical features varies from mild disease with only hair involvement to severe disease with cutaneous, neurologic and profound developmental defects. Ichthyosis, intellectual and developmental disabilities, decreased fertility, abnormal characteristics at birth, ocular abnormalities, short stature, and infections are common manifestations. There are both photosensitive and non-photosensitive forms of the disorder.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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