Mouse Anti-HNRNPU Recombinant Antibody (A256) (CBMAB-AP3158LY)

Heterogeneous Nuclear Ribonucleoprotein U

This gene encodes a member of a family of proteins that bind nucleic acids and function in the formation of ribonucleoprotein complexes in the nucleus with heterogeneous nuclear RNA (hnRNA). The encoded protein has affinity for both RNA and DNA, and binds scaffold-attached region (SAR) DNA. Mutations in this gene have been associated with epileptic encephalopathy, early infantile, 54. A pseudogene of this gene has been identified on chromosome 14. [provided by RefSeq, Jun 2017]

Heterogeneous Nuclear Ribonucleoprotein U; Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A); Nuclear P120 Ribonucleoprotein; HNRNPU Antisense RNA 1; HnRNP U; GRIP120; HNRPU; SAF-A; U21.1; Pp120; SAFA;

CSB-MA995761

Adaptive thermogenesis Source: UniProtKB
Cardiac muscle cell development Source: Ensembl
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cellular response to glucocorticoid stimulus Source: UniProtKB
Cellular response to leukemia inhibitory factor Source: UniProtKB
Circadian regulation of gene expression Source: UniProtKB
CRD-mediated mRNA stabilization Source: ComplexPortal
Dendritic transport of messenger ribonucleoprotein complex Source: Ensembl
Dosage compensation by inactivation of X chromosome Source: UniProtKB
Maintenance of protein location in nucleus Source: UniProtKB
mRNA splicing, via spliceosome Source: UniProtKB
mRNA stabilization Source: UniProtKB
Negative regulation of kinase activity Source: UniProtKB
Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: ComplexPortal
Negative regulation of stem cell differentiation Source: UniProtKB
Negative regulation of telomere maintenance via telomerase Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Negative regulation of transcription elongation from RNA polymerase II promoter Source: UniProtKB
Osteoblast differentiation Source: UniProtKB
Positive regulation of attachment of mitotic spindle microtubules to kinetochore Source: UniProtKB
Positive regulation of brown fat cell differentiation Source: UniProtKB
Positive regulation of cytoplasmic translation Source: ComplexPortal
Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity Source: UniProtKB
Positive regulation of stem cell proliferation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Protein localization to spindle microtubule Source: UniProtKB
Regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
Regulation of chromatin organization Source: UniProtKB
Regulation of mitotic cell cycle Source: UniProtKB
Regulation of mitotic spindle assembly Source: UniProtKB
RNA localization to chromatin Source: UniProtKB
RNA processing Source: ProtInc

Centrosome; Spindle; Spindle pole; Nucleus; Nucleus matrix; Nucleus speckle; Cytoplasm; Chromosome; Kinetochore; Midbody; Cell surface; Cytoplasmic granule. Localizes at inactive X chromosome (Xi) regions (PubMed:11003645, PubMed:14608463, PubMed:15563465). Localizes in the nucleus during interphase (PubMed:21242313). At metaphase, localizes with mitotic spindle microtubules (MTs) (PubMed:21242313). At anaphase, localizes in the mitotic spindle midzone (PubMed:21242313). Localizes in spindle MTs proximal to spindle poles in a TPX2- and AURKA-dependent manner (PubMed:21242313). The Ser-59 phosphorylated form localizes to centrosomes during prophase and metaphase, to mitotic spindles in anaphase and to the midbody during cytokinesis (PubMed:25986610). Colocalizes with SMARCA4 in the nucleus (By similarity). Colocalizes with CBX5 in the nucleus (PubMed:19617346). Colocalizes with NR3C1 in nuclear speckles (PubMed:9353307). Localized in cytoplasmic ribonucleoprotein (RNP) granules containing untranslated mRNAs (PubMed:17289661).

Developmental and epileptic encephalopathy 54 (DEE54):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent.

Cleaved at Asp-100 by CASP3 during T-cell apoptosis, resulting in a loss of DNA- and chromatin-binding activities (PubMed:9405365, PubMed:10671544).
Extensively phosphorylated (PubMed:7993898). Phosphorylated on Ser-59 by PLK1 and dephosphorylated by protein phosphatase 2A (PP2A) in mitosis (PubMed:25986610).
Arg-739 is dimethylated, probably to asymmetric dimethylarginine (Ref. 8). Arg-733 is dimethylated, probably to asymmetric dimethylarginine (By similarity).
Citrullinated by PADI4.