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Mouse Anti-HPV-11 E2 (AA 202-284) Recombinant Antibody (CBMW-H0358) (CBMAB-V208-0404-FY)


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Summary

Host Animal
Mouse
Specificity
HPV
Clone
CBMW-H0358
Antibody Isotype
IgG1
Application
WB, IF, ELISA

Basic Information

Immunogen
Recombinant full-length HPV-11 E2-protein purifiedfrom E. coli
Specificity
HPV
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 202-284

Target

Full Name
Human Papilloma Virus-11 E2
Introduction
An HPV infection is caused by human papillomavirus, a DNA virus from the papillomavirus family, of which over 170 types are known.
Alternative Names
HPV-11 E2; Human papilloma virus-11 E2
Function
Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.
Biological Process
DNA replication Source: UniProtKB-KW
Regulation of DNA replication Source: UniProtKB-UniRule
Transcription, DNA-templated Source: UniProtKB-UniRule
Viral DNA genome replication Source: UniProtKB-UniRule
Cellular Location
Host nucleus; Nucleus
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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