HPV-11 E2

An HPV infection is caused by human papillomavirus, a DNA virus from the papillomavirus family, of which over 170 types are known.

Full Name

Human Papilloma Virus-11 E2

Function

Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.

Biological Process

DNA replication Source: UniProtKB-KW
Regulation of DNA replication Source: UniProtKB-UniRule
Transcription, DNA-templated Source: UniProtKB-UniRule
Viral DNA genome replication Source: UniProtKB-UniRule

Cellular Location

Host nucleus; Nucleus

PTM

Phosphorylated.