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Mouse Anti-HPV-16 L1 Recombinant Antibody (CamVir-1) (CBMAB-V208-0985-FY)


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Summary

Host Animal
Mouse
Specificity
HPV
Clone
CamVir-1
Antibody Isotype
IgG2a, κ
Application
IF, IHC-P

Basic Information

Specificity
HPV
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.01% BSA
Preservative
0.05% Sodium azide
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
Human papillomavirus infection is an infection by human papillomavirus (HPV).
UniProt ID
P03101
Alternative Names
HPV-16 L1; Human papillomavirus type 16; HPV-16; L1; Major capsid protein L1
Function
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.
Biological Process
Endocytosis involved in viral entry into host cell Source: UniProtKB-KW
Virion attachment to host cell Source: UniProtKB-UniRule
Cellular Location
Virion; Host nucleus
PTM
ISGylated by host HERC5, this results in dominant-negative effect on virus infectivity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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