HPV-16 L1

Human papillomavirus infection is an infection by human papillomavirus (HPV). Most HPV infections cause no symptoms and resolve spontaneously. In some people, an HPV infection persists and results in warts or precancerous lesions. The precancerous lesions increase the risk of cancer of the cervix, vulva, vagina, penis, anus, mouth, or throat. Nearly all cervical cancer is due to HPV with two types, HPV16 and HPV18, accounting for 70% of cases. Between 60% and 90% of the other cancers are also linked to HPV. HPV6 and HPV11 are common causes of genital warts and laryngeal papillomatosis.
Full Name
Human papillomavirus type 16 Major capsid protein L1
Function
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.
Biological Process
Endocytosis involved in viral entry into host cell Source: UniProtKB-KW
Virion attachment to host cell Source: UniProtKB-UniRule
Cellular Location
Virion; Host nucleus
PTM
ISGylated by host HERC5, this results in dominant-negative effect on virus infectivity.
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Anti-HPV-16 L1 antibodies

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Mouse Anti-HPV-16 L1 Recombinant Antibody (SPM257) (CBMAB-V208-1723-CQ)

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Target: HPV-16 L1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: HPV-16
Clone: SPM257
Application*: P, IF
Datasheet SDS

Mouse Anti-HPV-16 L1 Recombinant Antibody (CBMW-H1110) (CBMAB-V208-1269-FY)

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Target: HPV-16 L1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: HPV
Clone: CBMW-H1110
Application*: P, IP, WB
Datasheet SDS

Mouse Anti-HPV-16 L1 Recombinant Antibody (CBMW-H0860) (CBMAB-V208-0994-FY)

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Target: HPV-16 L1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: HPV
Clone: CBMW-H0860
Application*: E
Datasheet SDS

Mouse Anti-HPV-16 L1 Recombinant Antibody (CBMW-H0856) (CBMAB-V208-0989-FY)

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Target: HPV-16 L1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: HPV
Clone: CBMW-H0856
Application*: IH, IP, WB
Datasheet SDS

Mouse Anti-HPV-16 L1 Recombinant Antibody (CBMW-H0854) (CBMAB-V208-0986-FY)

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Target: HPV-16 L1
Host: Mouse
Antibody Isotype: IgG
Specificity: HPV
Clone: CBMW-H0854
Application*: E, P, C, IF, IP
Datasheet SDS

Mouse Anti-HPV-16 L1 Recombinant Antibody (CamVir-1) (CBMAB-V208-0985-FY)

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Target: HPV-16 L1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: HPV
Clone: CamVir-1
Application*: IF, P
Datasheet SDS

Mouse Anti-HPV-16 L1 (AA 289-16981) Recombinant Antibody (CBMW-H0374) (CBMAB-V208-0422-FY)

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Target: HPV-16 L1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: HPV
Clone: CBMW-H0374
Application*: WB, IP, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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