Mouse Anti-IBSP Recombinant Antibody (CBYY-I1862) (CBMAB-I3032-YY)

Name: Mouse Anti-IBSP Recombinant Antibody (CBYY-I1862)
SKU: CBMAB-I3032-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-I1862

Application

ELISA, ICC, IHC-Fr, IHC-P, RIA, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

pH 7.2, 50 mM Tris

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Integrin Binding Sialoprotein

Introduction

The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.

Entrez Gene ID

443539

UniProt ID

P21621

Alternative Names

Integrin Binding Sialoprotein

Function

Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.

Biological Process

Bone mineralization Source: GO_Central
Cell adhesion Source: UniProtKB
Cellular response to growth factor stimulus Source: UniProtKB
Extracellular matrix organization Source: UniProtKB
Osteoblast differentiation Source: UniProtKB
Positive regulation of cell adhesion Source: CAFA

Cellular Location

Secreted

PTM

N-glycosylated; glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains.
O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc.
Sulfated on either Tyr-313 or Tyr-314.

Ghochani, Y., Muthukrishnan, S. D., Sohrabi, A., Kawaguchi, R., Condro, M. C., Bastola, S., ... & Kornblum, H. I. (2022). A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration. Cell reports, 41(3).

Ghochani, Y., Sohrabi, A., Muthukrishnan, S. D., Kawaguchi, R., Condro, M. C., Bastola, S., ... & Kornblum, H. I. (2021). Generation of a molecular interactome of the glioblastoma perivascular niche reveals Integrin Binding Sialoprotein as a key mediator of tumor cell migration. bioRxiv, 2021-10.

Wu, K., Feng, J., Lyu, F., Xing, F., Sharma, S., Liu, Y., ... & Watabe, K. (2021). Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer. Nature Communications, 12(1), 5196.

Hu, L., Liu, J., Xue, H., Panayi, A. C., Xie, X., Lin, Z., ... & Liu, G. (2021). miRNA-92a-3p regulates osteoblast differentiation in patients with concomitant limb fractures and TBI via IBSP/PI3K-AKT inhibition. Molecular Therapy-Nucleic Acids, 23, 1345-1359.

Wang, M., Liu, B., Li, D., Wu, Y., Wu, X., Jiao, S., ... & Tang, H. (2019). Upregulation of IBSP expression predicts poor prognosis in patients with esophageal squamous cell carcinoma. Frontiers in Oncology, 9, 1117.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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