Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-IFNE1 Recombinant Antibody (3B8) (CBMAB-A4284-LY)


See all IFNE1 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
3B8
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
IFNE1 (NP_795372, 109 a.a. ~ 208 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
interferon, epsilon
Entrez Gene ID
3458
UniProt ID
P01579
Alternative Names
IFN-E; IFNE1; IFNT1; MGC119018; MGC119020; PRO655
Function
Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity).
Biological Process
Adaptive immune response Source: GO_Central
B cell differentiation Source: GO_Central
B cell proliferation Source: GO_Central
Cytokine-mediated signaling pathway Source: GO_Central
Defense response to bacterium Source: UniProtKB
Defense response to virus Source: UniProtKB
Humoral immune response Source: GO_Central
Natural killer cell activation involved in immune response Source: GO_Central
Positive regulation of peptidyl-serine phosphorylation of STAT protein Source: GO_Central
Response to exogenous dsRNA Source: GO_Central
T cell activation involved in immune response Source: GO_Central
Cellular Location
Secreted
More Infomation

Taylor, B. D., Criscitiello, M. F., Bazer, F. W., Richardson, L. S., Noah, A., & Haggerty, C. L. (2023). Functional interferon‐epsilon gene polymorphisms and sexually transmitted infections of the endometrium. American Journal of Reproductive Immunology, 90(2), e13754.

Ahmad, H. I., Jameel, L., Zahra, Q., Zhou, J., Li, L., Zhang, X., ... & Chen, J. (2023). Molecular Evolution of Interferon-Epsilon (IFNε) Pseudogene Modulates Innate and Specific Antiviral Immunity in Manis javanica. Journal of Zoological Systematics and Evolutionary Research, 2023.

Gu, Z., Liu, J., Qin, L., Zhang, Y., Cui, W., Huang, H., ... & Zhang, H. (2023). WTAP-mediated m6A modification of IFNE is required for antiviral defense in condyloma acuminata. Journal of Dermatological Science.

Miller, D., Romero, R., Kacerovsky, M., Musilova, I., Galaz, J., Garcia-Flores, V., ... & Gomez-Lopez, N. (2022). Defining a role for Interferon Epsilon in normal and complicated pregnancies. Heliyon, 8(7), e09952.

Barriga, F. M., Tsanov, K. M., Ho, Y. J., Sohail, N., Zhang, A., Baslan, T., ... & Lowe, S. W. (2022). MACHETE identifies interferon-encompassing chromosome 9p21. 3 deletions as mediators of immune evasion and metastasis. Nature Cancer, 3(11), 1367-1385.

Taylor, B. D., Criscitiello, M. F., Hernandez, T., Norwood, B., Noah, A. I., & Bazer, F. W. (2022). Interferon epsilon and preterm birth subtypes; a new piece of the type I interferon puzzle during pregnancy?. American Journal of Reproductive Immunology, 87(4), e13526.

Marks, Z. R., Campbell, N., deWeerd, N. A., Lim, S. S., Gearing, L. J., Bourke, N. M., & Hertzog, P. J. (2019, June). Properties and functions of the novel type I interferon epsilon. In Seminars in Immunology (Vol. 43, p. 101328). Academic Press.

Nickodem, C., Criscitiello, M. F., Bazer, F., Abiodun‐Ojo, O., & Taylor, B. D. (2018). Interferon epsilon in the reproductive tract of healthy and genital herpes simplex virus‐infected pregnant women: Results of a pilot study. American Journal of Reproductive Immunology, 80(3), e12995.

Fischer, C. D., Wachoski-Dark, G. L., Grant, D. M., Bramer, S. A., & Klein, C. (2018). Interferon epsilon is constitutively expressed in equine endometrium and up-regulated during the luteal phase. Animal reproduction science, 195, 38-43.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-IFNE1 Recombinant Antibody (3B8)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry