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Mouse Anti-IRGM Recombinant Antibody (CBFYM-1157) (CBMAB-M1314-FY)

This product is mouse antibody that recognizes IRGM. The antibody CBFYM-1157 can be used for immunoassay techniques such as: WB, ELISA.
See all IRGM antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBFYM-1157
Antibody Isotype
IgM
Application
WB, ELISA

Basic Information

Immunogen
Purified His-tagged Mouse Irgm1 protein was used to produced this monoclonal antibody
Specificity
Human, Mouse
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.09% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Immunity Related GTPase M
Introduction
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
Human345611
Mouse15944
UniProt ID
HumanA1A4Y4
MouseQ60766
Alternative Names
Immunity Related GTPase M
Function
Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).
Biological Process
Autophagosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
CAMKK-AMPK signaling cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to interferon-betaManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to virusManual Assertion Based On ExperimentIMP:UniProtKB
Defense responseManual Assertion Based On ExperimentIBA:GO_Central
Defense response to bacteriumManual Assertion Based On ExperimentIMP:UniProtKB
Defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIMP:UniProtKB
Inflammatory responseIEA:UniProtKB-KW
Innate immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Nucleotide-binding oligomerization domain containing 2 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of autophagosome maturationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of autophagyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interferon-gamma-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of peptidyl-threonine phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein serine/threonine kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Protein destabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Protein lipidation involved in autophagosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Protein stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of protein complex stabilityManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Golgi apparatus membrane; Cell membrane; Cytoplasmic vesicle, phagosome membrane; Cytoplasmic vesicle, autophagosome membrane; Cell projection, phagocytic cup. Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi.
Involvement in disease
Inflammatory bowel disease 19 (IBD19):
A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

Ali, A. Y., Medhat, B. M., Ashour, S. S., Badr, A. M., Dorgham, D., Ramadan, H., & Behiry, M. E. (2023). Evaluation of Immunity-related GTPase Family M Protein (IRGM) SNPs among Egyptian Lupus Patients: A Case-control Study. Current Rheumatology Reviews, 19(4), 463-469.

Wilburn, K. M., Meade, R. K., Heckenberg, E. M., Dockterman, J., Coers, J., Sassetti, C. M., ... & Smith, C. M. (2023). Differential requirement for IRGM proteins during tuberculosis infection in mice. Infection and Immunity, 91(2), e00510-22.

Goswami, A. B., Karadarević, D., & Castaño-Rodríguez, N. (2022). Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis. Inflammation Research, 71(7-8), 785-795.

Jena, K. K., Mehto, S., Nath, P., Chauhan, N. R., Sahu, R., Dhar, K., ... & Chauhan, S. (2020). Autoimmunity gene IRGM suppresses cGAS‐STING and RIG‐I‐MAVS signaling to control interferon response. EMBO reports, 21(9), e50051.

Finethy, R., Dockterman, J., Kutsch, M., Orench‐Rivera, N., Wallace, G. D., Piro, A. S., ... & Coers, J. (2020). Dynamin‐related Irgm proteins modulate LPS‐induced caspase‐11 activation and septic shock. EMBO reports, 21(11), e50830.

Xu, Y., Liu, R., Liao, C., Liu, J., Zhao, H., Li, Z., ... & Li, W. (2019). High expression of immunity-related GTPase family M protein in glioma promotes cell proliferation and autophagy protein expression. Pathology-Research and Practice, 215(1), 90-96.

Simon, T. G., Deng, X., Liu, C. T., Chung, R. T., & Long, M. T. (2019). The immunity‐related GTPase M rs13361189 variant does not increase the risk for prevalent or incident steatosis; results from the Framingham Heart Study. Liver International, 39(6), 1022-1026.

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For research use only. Not intended for any clinical use.

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