Mouse Anti-ISG20 Monoclonal Antibody (CBFYH-3281) (CBMAB-H3623-FY)

Name: Mouse Anti-ISG20 Monoclonal Antibody (CBFYH-3281)
SKU: CBMAB-H3623-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-3281

Application

ELISA, IF, WB

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Interferon Stimulated Exonuclease Gene 20

Introduction

ISG20 (Interferon Stimulated Exonuclease Gene 20) is a Protein Coding gene. Diseases associated with ISG20 include Hepatitis C and Viral Infectious Disease. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and 3-5-exoribonuclease activity. An important paralog of this gene is AEN.

Entrez Gene ID

3669

UniProt ID

Q96AZ6

Alternative Names

Interferon Stimulated Exonuclease Gene 20

Function

Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.

Biological Process

Defense response to virusManual Assertion Based On ExperimentIMP:UniProtKB
DNA catabolic process, exonucleolyticManual Assertion Based On ExperimentIDA:UniProtKB
Innate immune responseIEA:UniProtKB-KW
Negative regulation of viral genome replicationManual Assertion Based On ExperimentIMP:UniProtKB
Response to virusManual Assertion Based On ExperimentIDA:UniProtKB
RNA catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
rRNA processingIEA:UniProtKB-KW

Cellular Location

Nucleus; Nucleus, nucleolus; Cytoplasm; Nucleus, Cajal body

Chen, Z., Yin, M., Jia, H., Chen, Q., & Zhang, H. (2023). ISG20 stimulates anti-tumor immunity via a double-stranded RNA-induced interferon response in ovarian cancer. Frontiers in Immunology, 14, 1176103.

Liu, S. Y., Huang, M., Fung, T. S., Chen, R. A., & Liu, D. X. (2023). Characterization of the induction kinetics and antiviral functions of IRF1, ISG15 and ISG20 in cells infected with gammacoronavirus avian infectious bronchitis virus. Virology, 582, 114-127.

Imam, H., Kim, G. W., Mir, S. A., Khan, M., & Siddiqui, A. (2020). Interferon-stimulated gene 20 (ISG20) selectively degrades N6-methyladenosine modified Hepatitis B Virus transcripts. PLoS pathogens, 16(2), e1008338.

Weiss, C. M., Trobaugh, D. W., Sun, C., Lucas, T. M., Diamond, M. S., Ryman, K. D., & Klimstra, W. B. (2018). The interferon-induced exonuclease ISG20 exerts antiviral activity through upregulation of type i interferon response proteins. Msphere, 3(5), e00209-18.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

ISG20 Matched Antibody Pair (649) (CAT#: APMAB-649LY)

Related Products

ISG20 Matched Antibody Pair (649) (CAT#: APMAB-649LY)

Mouse Anti-ISG20 Recombinant Antibody (S1) (CAT#: CBMAB-A4561-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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