ISG20

ISG20 (Interferon Stimulated Exonuclease Gene 20) is a Protein Coding gene. Diseases associated with ISG20 include Hepatitis C and Viral Infectious Disease. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and 3-5-exoribonuclease activity. An important paralog of this gene is AEN.

Full Name

Interferon Stimulated Exonuclease Gene 20

Function

Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.

Biological Process

Defense response to virusManual Assertion Based On ExperimentIMP:UniProtKB
DNA catabolic process, exonucleolyticManual Assertion Based On ExperimentIDA:UniProtKB
Innate immune responseIEA:UniProtKB-KW
Negative regulation of viral genome replicationManual Assertion Based On ExperimentIMP:UniProtKB
Response to virusManual Assertion Based On ExperimentIDA:UniProtKB
RNA catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
rRNA processingIEA:UniProtKB-KW

Cellular Location

Nucleus; Nucleus, nucleolus; Cytoplasm; Nucleus, Cajal body