Mouse Anti-JMJD4 Recombinant Antibody (D-10) (CBMAB-0312-WJ)

This product is a mouse antibody that recognizes JMJD4. The antibody D-10 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all JMJD4 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

D-10

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Jumonji Domain Containing 4

Introduction

JMJD4 (Jumonji Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is JMJD6.

Entrez Gene ID

65094

UniProt ID

Q9H9V9

Alternative Names

JMJD4; jumonji domain containing 4

Function

Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1.

Biological Process

Histone H4-R3 methylationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of translational terminationManual Assertion Based On ExperimentIMP:UniProtKB
Protein hydroxylationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm

References

Tang, Y., Feng, M., Su, Y., Ma, T., Zhang, H., Wu, H., ... & Xu, D. (2023). Jmjd4 Facilitates Pkm2 Degradation in Cardiomyocytes and Is Protective Against Dilated Cardiomyopathy. Circulation, 147(22), 1684-1704.

Elsayed, W. S., Harb, O. A., Alabiad, M. A., Saad, R. H. F., Anbaig, A., Alorini, M., ... & Ali, R. M. (2023). Protein Expression of NEK2, JMJD4, and REST in Clear Cell Renal Cell Carcinoma (ccRCC): Clinical, Pathological, and Prognostic Findings. Iranian Journal of Pathology, 18(2), 180.

Li, Z., Zhou, Y., Jia, K., Yang, Y., Zhang, L., Wang, S., ... & Hou, J. (2022). JMJD4-demethylated RIG-I prevents hepatic steatosis and carcinogenesis. Journal of Hematology & Oncology, 15(1), 1-19.

Yan, H., Bao, Y., & Lin, Z. (2021). High Expression of JMJD4 Is a Potential Diagnostic and Prognostic Marker of Renal Cell Carcinoma. Disease Markers, 2021.

Aertker, K. (2021). Studies on recently identified activities of the Jumonji-C oxygenase JMJD4 and the bacterial class D nucleophilic serine β-lactamases (Doctoral dissertation, University of Oxford).

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-JMJD4 Recombinant Antibody (A722)

Mouse Anti-JMJD4 Recombinant Antibody (A721)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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