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Mouse Anti-KCNMB2 Recombinant Antibody (S53-32) (CBMAB-K0058-LY)

This product is antibody recognizes KCNMB2. The antibody S53-32 immunoassay techniques such as: ICC, IHC, WB, IP.
See all KCNMB2 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
S53-32
Antibody Isotype
IgG1
Application
ICC, IHC, WB, IP

Basic Information

Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% Glycerol
Preservative
0.09% sodium azide
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 2
Introduction
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]
Entrez Gene ID
72413
UniProt ID
Q9CZM9
Alternative Names
2700049B16Rik; 3110031N04Rik
Function
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.
Biological Process
Action potentialManual Assertion Based On ExperimentIDA:UniProtKB
Detection of calcium ionManual Assertion Based On ExperimentIDA:UniProtKB
Neuronal action potentialManual Assertion Based On ExperimentIDA:UniProtKB
Potassium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of vasoconstrictionManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Membrane
Topology
Cytoplasmic: 1-46
Helical: 47-67
Extracellular: 68-194
Helical: 195-215
Cytoplasmic: 216-235
PTM
N-glycosylated.

Yang, H., Wang, Z., & Wang, Z. (2022). Long Noncoding RNA KCNMB2-AS1 Increases ROCK1 Expression by Sponging microRNA-374a-3p to Facilitate the Progression of Non–Small-Cell Lung Cancer [Retraction]. Cancer Management and Research, 14, 2457-2458.

Moldenhauer, H. J., Dinsdale, R. L., Alvarez, S., Fernández-Jaén, A., & Meredith, A. L. (2022). Effect of an autism-associated KCNMB2 variant, G124R, on BK channel properties. Current research in physiology, 5, 404-413.

Xu, J., Liu, X., Liu, X., & Zhi, Y. (2021). Long noncoding RNA KCNMB2-AS1 promotes the development of esophageal cancer by modulating the miR-3194-3p/PYGL axis. Bioengineered, 12(1), 6687-6702.

Chen, Y. S., Xu, Y. P., Liu, W. H., Li, D. C., Wang, H., & Li, C. F. (2021). Long noncoding RNA KCNMB2-AS1 promotes SMAD5 by targeting miR-3194-3p to induce bladder cancer progression. Frontiers in Oncology, 11, 649778.

Dugan, A. J., Nelson, P. T., Katsumata, Y., Shade, L. M., Boehme, K. L., Teylan, M. A., ... & Fardo, D. W. (2021). Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study. Acta Neuropathologica Communications, 9, 1-18.

Zhu, J., Huang, Y., Zhang, Y., Huang, R., & Huang, C. (2021). KCNMB2-AS1 promotes bladder cancer progression through sponging miR-374a-3p to upregulate S100A10. Frontiers in Genetics, 12, 655569.

Zhang, Y., Wang, D., Wu, D., Zhang, D., & Sun, M. (2020). Long noncoding RNA KCNMB2-AS1 stabilized by N6-methyladenosine modification promotes cervical cancer growth through acting as a competing endogenous RNA. Cell Transplantation, 29, 0963689720964382.

Yang, H., Wang, Z., & Wang, Z. (2020). RETRACTED ARTICLE: Long Noncoding RNA KCNMB2-AS1 Increases ROCK1 Expression by Sponging microRNA-374a-3p to Facilitate the Progression of Non–Small-Cell Lung Cancer. Cancer management and research, 12679-12695.

Yoon, H. Y., Park, J. Y., Yee, J., Hwang, H. S., Chung, J. E., Lee, K. E., ... & Gwak, H. S. (2020). Effects of KCNMB2 gene polymorphisms on ritodrine therapy outcomes in women with preterm labor. Pharmacogenetics and Genomics, 30(6), 124-130.

Yu, M., Guo, L., Li, N., Henzel, K. S., Gu, H., Ran, X., ... & Zhou, Y. (2018). Overexpression of Kcnmb2 in dorsal CA1 of offspring mice rescues hippocampal dysfunction caused by a methyl donor-rich paternal diet. Frontiers in Cellular Neuroscience, 12, 360.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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