Mouse Anti-KRT9 Recombinant Antibody (Ks9.70 + Ks9.216) (CBMAB-C5444WJ)

Name: Mouse Anti-KRT9 Recombinant Antibody (Ks9.70 + Ks9.216)
SKU: CBMAB-C5444WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

Ks9.70 + Ks9.216

Application

IHC-P, IF, WB

Immunogen

Human cytokeratin 9

Specificity

Human, Mouse

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Keratin 9

Introduction

This gene encodes the type I keratin 9, an intermediate filament chain expressed only in the terminally differentiated epidermis of palms and soles. Mutations in this gene cause epidermolytic palmoplantar keratoderma. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	3857
Mouse	107656

UniProt ID

Human	P35527
Mouse	Q6RHW0

Alternative Names

Keratin 9; Type I Cytoskeletal 9; Keratin 9, Type I; Cytokeratin 9; CK-9; K9;

Function

May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly.

Biological Process

Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Intermediate filament organizationManual Assertion Based On ExperimentIMP:UniProtKB
Skin developmentManual Assertion Based On ExperimentIDA:UniProtKB
SpermatogenesisIEA:Ensembl

Cellular Location

Cytosol
Extracellular exosome
Extracellular space
Intermediate filament
Membrane
Nucleus

Involvement in disease

Keratoderma, palmoplantar, epidermolytic (EPPK):
A dermatological disorder characterized by diffuse thickening of the epidermis on the entire surface of palms and soles sharply bordered with erythematous margins. Some patients may present knuckle pads, thick pads of skin appearing over the proximal phalangeal joints.

Li, P., Qi, J., Zhong, Y., Ding, A., & Xiao, H. (2023). Proteomic profiling reveals KRT6C as a probable hereterodimer partner for KRT9: New insights into re-classifying epidermolytic palmoplantar keratoderma (EPPK) and a milder form of pachyonychia congenita (PC-K6c) as a group of genetic cutaneous disorders. Journal of Proteomics, 287, 104971.

Liu, X., Qiu, C., He, R., Zhang, Y., & Zhao, Y. (2019). Keratin 9 L164P mutation in a Chinese pedigree with epidermolytic palmoplantar keratoderma, cytokeratin analysis, and literature review. Molecular Genetics & Genomic Medicine, 7(11), e977.

Xiao, H., Guo, Y., Yi, J., Xia, H., Xu, H., Yuan, L., ... & Deng, H. (2018). Identification of a novel keratin 9 missense mutation in a Chinese family with epidermolytic palmoplantar keratoderma. Cellular Physiology and Biochemistry, 46(5), 1919-1929.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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