Mouse Anti-LCN1 Recombinant Antibody (10B10) (CBMAB-L0826-YJ)

Name: Mouse Anti-LCN1 Recombinant Antibody (10B10)
SKU: CBMAB-L0826-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

10B10

Application

WB, IF

Immunogen

Purified recombinant fragment of LCN1 expressed in E. coli.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Preservative

0.03% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Lipocalin 1

Introduction

lipocalin 1 (LCN1) is a member of the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. LCN1 is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. LCN1 may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and two pseudogenes of this gene are also located on the long arm of chromosome 9.

Entrez Gene ID

3933

UniProt ID

P31025

Alternative Names

Lipocalin 1; Von Ebner Gland Protein; Tear Prealbumin; Tear Lipocalin; VEG Protein; VEGP; TP; Lipocalin 1 (Protein Migrating Faster Than Albumin, Tear Prealbumin);Protein Migrating Faster Than Albumin; Lipocalin 1 (Tear Prealbumin); Lipocalin 1-Like 2; Lipocalin-1; PMFA; TLC; Tlc

Function

Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.

Biological Process

ProteolysisManual Assertion Based On ExperimentTAS:ProtInc
Response to stimulusIEA:UniProtKB-KW
Retina homeostasisManual Assertion Based On ExperimentHEP:UniProtKB
Sensory perception of tasteIEA:UniProtKB-KW

Cellular Location

Secreted

Yao, J., Liu, Y., Jiang, B., Yuan, R., & Xiang, Y. (2023). An aptamer triple helix molecular switch for sensitive electrochemical assay of lipocalin 1 biomarker via dual signal amplifications. Analyst, 148(12), 2739-2744.

Bhatia, R., Gautam, P., Sharma, I., Beri, N., Sahu, P. K., & Das, G. K. (2023). Study of the association of lipocalin-1 in tears with the progression of diabetic retinopathy: Cross-sectional comparative study. The Pan-American Journal of Ophthalmology, 5(1), 33.

Zhang, X., Cui, Y., He, M., Jiao, Y., & Yang, Z. (2020). Lipocalin-1 expression as a prognosticator marker of survival in breast cancer patients. Breast Care, 15(3), 272-280.

Gao, S., Zhang, S., Sun, X., Zheng, X., & Wu, J. (2020). Fluorescent aptasensor based on G-quadruplex-assisted structural transformation for the detection of biomarker lipocalin 1. Biosensors and Bioelectronics, 169, 112607.

Yang, Y., Li, F., Luo, X., Jia, B., Zhao, X., Liu, B., ... & He, J. (2019). Identification of LCN1 as a potential biomarker for breast cancer by bioinformatic analysis. DNA and Cell Biology, 38(10), 1088-1099.

Jia, W., Lu, Z., Yang, H., Li, H., & Xu, D. (2018). Elimination terminal fixed region screening and high-throughput kinetic determination of aptamer for lipocalin-1 by surface plasmon resonance imaging. Analytica chimica acta, 1043, 158-166.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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