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LCN1

This gene encodes a member of the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. The encoded protein is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. The encoded protein may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and two pseudogenes of this gene are also located on the long arm of chromosome 9. [provided by RefSeq, Nov 2011]LCN1 (Lipocalin 1) is a Protein Coding gene. Diseases associated with LCN1 include Dry Eye Syndrome and Stromal Keratitis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of vitamins, nucleosides, and related molecules. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is OBP2B.Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.

Full Name

Lipocalin 1

Function

Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.

Biological Process

ProteolysisManual Assertion Based On ExperimentTAS:ProtInc
Response to stimulusIEA:UniProtKB-KW
Retina homeostasisManual Assertion Based On ExperimentHEP:UniProtKB
Sensory perception of tasteIEA:UniProtKB-KW

Cellular Location

Secreted

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Anti-LCN1 antibodies

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Mouse Anti-LCN1 Recombinant Antibody (CBYJT-1415) (CBMAB-T0438-YJ)

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Target: LCN1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-1415

Application*: WB, IC, P, C, E

Mouse Anti-LCN1 Recombinant Antibody (CBYCL-162) (CBMAB-L0063-YC)

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Target: LCN1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYCL-162

Application*: E, WB

Mouse Anti-LCN1 Recombinant Antibody (CBYCL-161) (CBMAB-L0062-YC)

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Target: LCN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYCL-161

Application*: E, WB, P, IF, IC

Mouse Anti-LCN1 Recombinant Antibody (CBYJL-1269) (CBMAB-L0835-YJ)

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Target: LCN1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-1269

Application*: WB, IP, IF, E

Mouse Anti-LCN1 Recombinant Antibody (7H4H6) (CBMAB-L0834-YJ)

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Target: LCN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 7H4H6

Application*: E, ED

Mouse Anti-LCN1 Recombinant Antibody (1K45) (CBMAB-L0832-YJ)

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Target: LCN1

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: 1K45

Application*: WB

Mouse Anti-LCN1 Recombinant Antibody (CBYJL-1267) (CBMAB-L0831-YJ)

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Target: LCN1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-1267

Application*: EC

Mouse Anti-LCN1 Recombinant Antibody (CBYJL-1265) (CBMAB-L0828-YJ)

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Target: LCN1

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBYJL-1265

Application*: WB

Mouse Anti-LCN1 Recombinant Antibody (13B473) (CBMAB-L0827-YJ)

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Target: LCN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 13B473

Application*: E, IH, WB

Mouse Anti-LCN1 Recombinant Antibody (10B10) (CBMAB-L0826-YJ)

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Target: LCN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10B10

Application*: WB, IF

Mouse Anti-LCN1 Recombinant Antibody (CBT846) (V2LY-0625-LY3234)

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Target: LCN1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBT846

Application*: WB, P, IF, IC, E

Mouse Anti-LCN1 Recombinant Antibody (CBT3193) (V2LY-0625-LY2337)

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Target: LCN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT3193

Application*: IH, IC

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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