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Mouse Anti-MAST1 Recombinant Antibody (CBXS-4263) (CBMAB-S1513-CQ)

This product is a mouse antibody that recognizes MAST1. The antibody CBXS-4263 can be used for immunoassay techniques such as: WB, IP, IF.
See all MAST1 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBXS-4263
Application
WB, IP, IF

Basic Information

Specificity
Rat
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
microtubule associated serine/threonine kinase 1
Introduction
This gene is a member of the microtubule-associated serine/threonine kinase (MAST) family. The protein encoded by this gene has an N-terminal serine/threonine kinase domain followed by a postsynaptic density protein-95/discs large/zona occludens-1 (PDZ) domain. In mouse and rat, the orthologous protein associates with the cytoskeleton and can bind both beta-2-syntrophin and neuronal nitric oxide synthase (nNOS) through its PDZ domain. In mouse and rat, this protein also co-localizes with dystrophin- and utrophin-associated protein complexes (DAPC/UAPC) in the vascular endothelium of the central nervous system.
Entrez Gene ID
353118
UniProt ID
Q810W7
Alternative Names
Sast
Function
Microtubule-associated protein essential for correct brain development (PubMed:30449657).

Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity).
Biological Process
Brain development Source: UniProtKB
Cytoskeleton organization Source: UniProtKB
Intracellular signal transduction Source: UniProtKB
Peptidyl-serine phosphorylation Source: GO_Central
Protein phosphorylation Source: UniProtKB
Cellular Location
Plasma membrane
Cell membrane
Cytoskeleton
Other locations
axon
dendrite
Note: Also localized in the soma of neurons. Observed as punctate clusters in the processes of interneurons and along the cell body periphery. Colocalizes with syntrophins at the cell membrane.
Involvement in disease
Mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations (MCCCHCM):
An autosomal dominant neurodevelopmental disorder with onset in infancy. MCCCHCM is characterized by global developmental delay, impaired intellectual development, poor or absent speech, unsteady gait, ataxia, inability to walk, and variable brain abnormalities. Seizures and autistic features are observed in some patients. Brain imaging findings include an enlarged corpus callosum in the absence of megalencephaly, cerebellar hypoplasia, ventricular dilation, gyral abnormalities, and cortical malformations.

Sloboda, N., Renard, E., Lambert, L., Bonnet, C., Leheup, B., Todosi, C., ... & Renaud, M. (2023). MAST1-related mega-corpus-callosum syndrome with central hypogonadism. European Journal of Medical Genetics, 66(11), 104853.

Tyagi, A., Kaushal, K., Chandrasekaran, A. P., Sarodaya, N., Das, S., Park, C. H., ... & Ramakrishna, S. (2022). CRISPR/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells. Theranostics, 12(13), 5949.

Tan, B., Zhang, J., Wang, W., Ma, H., & Yang, Y. (2022). E3 Ubiquitin Ligase CHIP Inhibits the Interaction between Hsp90β and MAST1 to Repress Radiation Resistance in Non-Small-Cell Lung Cancer Stem Cells. Stem Cells International, 2022.

Pan, C., Kang, J., Hwang, J. S., Li, J., Boese, A. C., Wang, X., ... & Kang, S. (2021). Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1. Nature communications, 12(1), 4960.

Ding, W., Lu, Y., Zhou, A., Chen, Y., Wang, Z., Wang, L., & Tian, Y. (2021). Mast1 mediates radiation-induced gastric injury via the P38 MAPK pathway. Experimental Cell Research, 409(2), 112913.

Ben-Mahmoud, A., Al-Shamsi, A. M., Ali, B. R., & Al-Gazali, L. (2020). Evaluating the role of MAST1 as an intellectual disability disease gene: identification of a novel de novo variant in a patient with developmental disabilities. Journal of Molecular Neuroscience, 70, 320-327.

Rodríguez‐García, M. E., Cotrina‐Vinagre, F. J., Gómez‐Cano, M. D. L. Á., Martinez de Aragon, A., Martín‐Hernández, E., & Martínez‐Azorín, F. (2020). MAST1 variant causes mega‐corpus‐callosum syndrome with cortical malformations but without cerebellar hypoplasia. American journal of medical genetics Part A, 182(6), 1483-1490.

Hecher, L., Johannsen, J., Bierhals, T., Buhk, J. H., Hempel, M., & Denecke, J. (2020). The clinical picture of a bilateral perisylvian syndrome as the initial symptom of mega-corpus-callosum syndrome due to a MAST1-gene mutation. Neuropediatrics, 51(06), 435-439.

Jing, T., Ma, J., Zhao, H., Zhang, J., Jiang, N., & Ma, D. (2020). MAST1 modulates neuronal differentiation and cell cycle exit via P27 in neuroblastoma cells. FEBS Open bio, 10(6), 1104-1114.

Pan, C., Chun, J., Li, D., Boese, A. C., Li, J., Kang, J., ... & Kang, S. (2019). Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteosomal degradation. The Journal of clinical investigation, 129(10), 4110-4123.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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