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Mouse Anti-MATN3 Recombinant Antibody (CBFYM-1765) (CBMAB-M1933-FY)

This product is mouse antibody that recognizes MATN3. The antibody CBFYM-1765 can be used for immunoassay techniques such as: WB.
See all MATN3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1765
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 2% sucrose
Preservative
0.09% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MATRILIN 3
Introduction
This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains two von Willebrand factor A domains; it is present in the cartilage extracellular matrix and has a role in the development and homeostasis of cartilage and bone. Mutations in this gene result in multiple epiphyseal dysplasia.
Entrez Gene ID
4148
UniProt ID
O15232
Alternative Names
Matrilin 3; Matrilin-3; DIPOA; OADIP; EDM5; HOA; OS2
Function
Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.
Biological Process
Cartilage development Source: Ensembl
Extracellular matrix organization Source: ComplexPortal
Skeletal system development Source: ProtInc
Cellular Location
Secreted
Involvement in disease
Multiple epiphyseal dysplasia 5 (EDM5):
A generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. Radiological examination of the skeleton shows delayed, irregular mineralization of the epiphyseal ossification centers and of the centers of the carpal and tarsal bones. Multiple epiphyseal dysplasia is broadly categorized into the more severe Fairbank and the milder Ribbing types. The Fairbank type is characterized by shortness of stature, short and stubby fingers, small epiphyses in several joints, including the knee, ankle, hand, and hip. The Ribbing type is confined predominantly to the hip joints and is characterized by hands that are normal and stature that is normal or near-normal. Multiple epiphyseal dysplasia type 5 is relatively mild and clinically variable. It is primarily characterized by delayed and irregular ossification of the epiphyses and early-onset osteoarthritis.
Spondyloepimetaphyseal dysplasia, Borochowitz-Cormier-Daire type (SEMDBCD):
An autosomal recessive bone disease characterized by disproportionate early-onset dwarfism, bowing of the lower limbs, lumbar lordosis and normal hands. Skeletal abnormalities include short, wide and stocky long bones with severe epiphyseal and metaphyseal changes, hypoplastic iliac bones and flat, ovoid vertebral bodies.
Osteoarthritis 2 (OS2):
A degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. In the hand, osteoarthritis can develop in the distal interphalangeal and the first carpometacarpal (base of thumb) and proximal interphalangeal joints. Patients with osteoarthritis may have one, a few, or all of these sites affected.

Long, L., Zou, G., Cheng, Y., Li, F., Wu, H., & Shen, Y. (2023). MATN3 delivered by exosome from synovial mesenchymal stem cells relieves knee osteoarthritis: Evidence from in vitro and in vivo studies. Journal of Orthopaedic Translation, 41, 20-32.

Wang, P., Xiao, W. S., Li, Y. H., Wu, X. P., Zhu, H. B., & Tan, Y. R. (2021). Identification of MATN3 as a novel prognostic biomarker for gastric cancer through comprehensive TCGA and GEO data mining. Disease Markers, 2021.

Guo, Z., Su, W., Zhou, R., Zhang, G., Yang, S., Wu, X., ... & Xiang, H. (2021). Exosomal MATN3 of urine-derived stem cells ameliorates intervertebral disc degeneration by antisenescence effects and promotes NPC proliferation and ECM synthesis by activating TGF-β. Oxidative Medicine and Cellular Longevity, 2021.

Li, D., Xu, J., Dong, X., Chen, W., Pan, L., Jiang, H., ... & Huang, Y. (2021). Diagnostic and prognostic value of MATN3 expression in gastric carcinoma: TCGA database mining. Journal of Gastrointestinal Oncology, 12(4), 1374.

García-Alvarado, F. J., Delgado-Aguirre, H. A., Rosales-González, M., González-Martínez, M. D. R., Ruiz-Flores, P., González-Galarza, F. F., & Arellano Perez Vertti, R. D. (2020). Analysis of polymorphisms in the MATN3 and DOT1L genes and CTX-II urinary levels in patients with knee osteoarthritis in a Northeast Mexican-Mestizo population. Genetic Testing and molecular biomarkers, 24(2), 105-111.

Trivedi, V., Shah, R., Qidwai, S., AN, M., Raza, T., Kushwaha, S. S., ... & Khan, D. (2020). Association between MATN-3 gene polymorphism and primary knee osteoarthritis in indian population: a community-based case-control study. Fortune Journal of Rheumatology, 2(1), 1-12.

Zheng, G., Zhao, Y., & Zheng, Z. (2020). Overexpression of MATN3 predicts poor prognosis of gastric adenocarcinoma: based on TCGA database.

Shyamasundar, L. G., Loganathan, L., Kumar, A., Selina, A., & Madhuri, V. (2020). MATN3 mutation causing spondyloepimetaphyseal dysplasia. The Indian Journal of Pediatrics, 87, 227-228.

Yasin, S., Mustafa, S., Ayesha, A., Latif, M., Hassan, M., Faisal, M., ... & Naz, S. (2020). A novel homozygous missense variant in MATN3 causes Spondylo-epimetaphyseal dysplasia Matrilin 3 type in a consanguineous family. European Journal of Medical Genetics, 63(8), 103958.

Zhang, C., Liang, Y., Ma, M. H., Wu, K. Z., & Dai, D. Q. (2019). KRT15, INHBA, MATN3, and AGT are aberrantly methylated and differentially expressed in gastric cancer and associated with prognosis. Pathology-Research and Practice, 215(5), 893-899.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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