Mouse Anti-MCAT (AA 291-391) Recombinant Antibody (CBFYM-0481) (CBMAB-M0609-FY)

Name: Mouse Anti-MCAT (AA 291-391) Recombinant Antibody (CBFYM-0481)
SKU: CBMAB-M0609-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-0481

Application

ELISA, IHC, WB

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Preservative

0.09% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 291-391

More Infomation

Target

Full Name

Malonyl-CoA-Acyl Carrier Protein Transacylase

Introduction

The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms.

Entrez Gene ID

27349

UniProt ID

Q8IVS2

Alternative Names

Malonyl-CoA-Acyl Carrier Protein Transacylase; Malonyl CoA:ACP Acyltransferase (Mitochondrial); Mitochondrial Malonyl CoA:ACP Acyltransferase; [Acyl-Carrier-Protein] S-Malonyltransferase; [Acyl-Carrier-Protein] Malonyltransferase; Mitochondrial Malonyltransferase; MCT; MT

Function

Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria.

Biological Process

Fatty acid beta-oxidation Source: Reactome
Fatty acid biosynthetic process Source: UniProtKB

Cellular Location

Mitochondrion

Webb, B. D., Nowinski, S. M., Solmonson, A., Ganesh, J., Rodenburg, R. J., Leandro, J., ... & Houten, S. M. (2023). Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency. Elife, 12, e68047.

Gerber, S., Orssaud, C., Kaplan, J., Johansson, C., & Rozet, J. M. (2021). MCAT mutations cause nuclear LHON-like optic neuropathy. Genes, 12(4), 521.

Li, H., Yuan, S., Minegishi, Y., Suga, A., Yoshitake, K., Sheng, X., ... & Iwata, T. (2020). Novel mutations in malonyl-CoA-acyl carrier protein transacylase provoke autosomal recessive optic neuropathy. Human molecular genetics, 29(3), 444-458.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

MCAT Matched Antibody Pair (722) (CAT#: APMAB-722LY)

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Mouse Anti-MCAT (AA 291-391) Recombinant Antibody (CBFYM-1860) (CAT#: CBMAB-M2029-FY)

MCAT Matched Antibody Pair (722) (CAT#: APMAB-722LY)

Rabbit Anti-MCAT (N-terminus) Recombinant Antibody (CBFYM-1859) (CAT#: CBMAB-M2028-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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