Mouse Anti-MEIS1 (AA 176-390 ) Recombinant Antibody (CBFYM-2041) (CBMAB-M2221-FY)

Name: Mouse Anti-MEIS1 (AA 176-390 ) Recombinant Antibody (CBFYM-2041)
SKU: CBMAB-M2221-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2041

Application

WB, IHC

Immunogen

Human recombinant protein fragment corresponding to amino acids 176-390 of human MEIS1(NP_002389) produced in E.coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA

Preservative

0.02% Sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 176-390

More Infomation

Target

Full Name

MEIS HOMEOBOX 1

Introduction

Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE family of homeodomain-containing proteins.

Entrez Gene ID

4211

UniProt ID

O00470

Alternative Names

Meis Homeobox 1; Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog (Mouse); Meis1, Myeloid Ecotropic Viral Integration Site 1 Homolog; Leukemogenic Homolog Protein; Homeobox Protein Meis1; Meis1 (Mouse) Homolog; WUGSC:H_NH0444B04.1

Function

Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.

Biological Process

Angiogenesis Source: GO_Central
Animal organ morphogenesis Source: GO_Central
Brain development Source: GO_Central
Definitive hemopoiesis Source: Ensembl
Embryonic pattern specification Source: GO_Central
Eye development Source: GO_Central
Hemopoiesis Source: GO_Central
Lens morphogenesis in camera-type eye Source: Ensembl
Locomotory behavior Source: Ensembl
Megakaryocyte development Source: Ensembl
Negative regulation of myeloid cell differentiation Source: UniProtKB
Negative regulation of neuron differentiation Source: Ensembl
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Involvement in disease

Restless legs syndrome 7 (RLS7):
A neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep.

Coulombe, P., Cole, G., Fentiman, A., Parker, J. D., Yung, E., Bilenky, M., ... & Karsan, A. (2023). Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression. Nature Communications, 14(1), 4537.

Xiang, P., Yang, X., Escano, L., Dhillon, I., Schneider, E., Clemans-Gibbon, J., ... & Rouhi, A. (2022). Elucidating the importance and regulation of key enhancers for human MEIS1 expression. Leukemia, 36(8), 1980-1989.

Yao, M., Gu, Y., Yang, Z., Zhong, K., & Chen, Z. (2021). MEIS1 and its potential as a cancer therapeutic target. International Journal of Molecular Medicine, 48(3), 1-9.

Jiang, M., Xu, S., Bai, M., & Zhang, A. (2021). The emerging role of MEIS1 in cell proliferation and differentiation. American Journal of Physiology-Cell Physiology, 320(3), C264-C269.

Walker, A. R., Byrd, J. C., Blachly, J. S., Bhatnagar, B., Mims, A. S., Orwick, S., ... & Blum, W. G. (2020). Entospletinib in combination with induction chemotherapy in previously untreated acute myeloid leukemia: response and predictive significance of HOXA9 and MEIS1 expression. Clinical Cancer Research, 26(22), 5852-5859.

Whitlock, N. C., Trostel, S. Y., Wilkinson, S., Terrigino, N. T., Hennigan, S. T., Lake, R., ... & Sowalsky, A. G. (2020). MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity. Oncogene, 39(34), 5663-5674.

Salminen, A. V., Lam, D. D., & Winkelmann, J. (2019). Role of MEIS1 in restless legs syndrome: From GWAS to functional studies in mice. Advances in Pharmacology, 84, 175-184.

Johng, D., Torga, G., Ewing, C. M., Jin, K., Norris, J. D., McDonnell, D. P., & Isaacs, W. B. (2019). HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer. The Prostate, 79(4), 414-424.

Sarayloo, F., Dion, P. A., & Rouleau, G. A. (2019). MEIS1 and restless legs syndrome: a comprehensive review. Frontiers in neurology, 10, 935.

Lindgren, I. M., Drake, R. R., Chattergoon, N. N., & Thornburg, K. L. (2019). Down-regulation of MEIS1 promotes the maturation of oxidative phosphorylation in perinatal cardiomyocytes. The FASEB Journal, 33(6), 7417.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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