MEIS1

Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.

Full Name

MEIS HOMEOBOX 1

Function

Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.

Biological Process

Angiogenesis Source: GO_Central
Animal organ morphogenesis Source: GO_Central
Brain development Source: GO_Central
Definitive hemopoiesis Source: Ensembl
Embryonic pattern specification Source: GO_Central
Eye development Source: GO_Central
Hemopoiesis Source: GO_Central
Lens morphogenesis in camera-type eye Source: Ensembl
Locomotory behavior Source: Ensembl
Megakaryocyte development Source: Ensembl
Negative regulation of myeloid cell differentiation Source: UniProtKB
Negative regulation of neuron differentiation Source: Ensembl
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Involvement in disease

Restless legs syndrome 7 (RLS7):
A neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep.