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Rat Anti-MGLL Recombinant Antibody (CBFYM-2180) (CBMAB-M2362-FY)

This product is rat antibody that recognizes MGLL. The antibody CBFYM-2180 can be used for immunoassay techniques such as: FC, FuncS, IHC-Fr.
See all MGLL antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYM-2180
Antibody Isotype
IgG2a
Application
FC, FuncS, IHC-Fr

Basic Information

Immunogen
Murine mature macrophage cell lines
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% BSA
Preservative
0.02% Sodium azide
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Monoglyceride Lipase
Introduction
This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Entrez Gene ID
23945
UniProt ID
O35678
Alternative Names
Monoglyceride Lipase; Lysophospholipase Homolog; Monoacylglycerol Lipase; HU-K5; MAGL; MGL; Lysophospholipase-Like; EC 3.1.1.23; HUK5
Function
Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842).

Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842).

Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333).
Biological Process
Acylglycerol catabolic process Source: UniProtKB
Arachidonic acid metabolic process Source: UniProtKB
Fatty acid biosynthetic process Source: UniProtKB-KW
Inflammatory response Source: ProtInc
Lipid metabolic process Source: ProtInc
Monoacylglycerol catabolic process Source: UniProtKB
Regulation of endocannabinoid signaling pathway Source: UniProtKB
Regulation of inflammatory response Source: UniProtKB
Regulation of sensory perception of pain Source: UniProtKB
Regulation of signal transduction Source: UniProtKB
Triglyceride catabolic process Source: UniProtKB-UniPathway
Cellular Location
Cytosol
Other locations
Membrane

Gruden, E., Kienzl, M., Hasenoehrl, C., Sarsembayeva, A., Ristic, D., Schmid, S. T., ... & Schicho, R. (2023). Tumor microenvironment-derived monoacylglycerol lipase provokes tumor-specific immune responses and lipid profiles. Prostaglandins, Leukotrienes and Essential Fatty Acids, 196, 102585.

Matheson, J., Zhou, X. M. M., Bourgault, Z., & Le Foll, B. (2021). Potential of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL), and diacylglycerol lipase (DAGL) enzymes as targets for obesity treatment: A narrative review. Pharmaceuticals, 14(12), 1316.

Liu, R., Wang, X., Curtiss, C., Sheikh, M. S., & Huang, Y. (2020). Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein. Cell Death & Differentiation, 27(10), 2888-2903.

Tardelli, M. (2020). Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease. World Journal of Gastroenterology, 26(25), 3577.

Zhang, H., Guo, W., Zhang, F., Li, R., Zhou, Y., Shao, F., ... & He, J. (2020). Monoacylglycerol lipase knockdown inhibits cell proliferation and metastasis in lung adenocarcinoma. Frontiers in oncology, 10, 559568.

Tardelli, M., Bruschi, F. V., Fuchs, C. D., Claudel, T., Auer, N., Kunczer, V., ... & Trauner, M. (2020). Monoacylglycerol lipase inhibition protects from liver injury in mouse models of sclerosing cholangitis. Hepatology, 71(5), 1750-1765.

Tardelli, M., Bruschi, F. V., Claudel, T., Fuchs, C. D., Auer, N., Kunczer, V., ... & Trauner, M. (2019). Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption [S]. Journal of Lipid Research, 60(7), 1284-1292.

Yoshida, K., Kita, Y., Tokuoka, S. M., Hamano, F., Yamazaki, M., Sakimura, K., ... & Shimizu, T. (2019). Monoacylglycerol lipase deficiency affects diet‐induced obesity, fat absorption, and feeding behavior in CB1 cannabinoid receptor–deficient mice. The FASEB Journal, 33(2), 2484-2497.

Tang, W., Lan, D., Zhao, Z., Li, S., Li, X., & Wang, Y. (2019). A thermostable monoacylglycerol lipase from marine Geobacillus sp. 12AMOR1: biochemical characterization and mutagenesis study. International journal of molecular sciences, 20(3), 780.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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