MGLL

This gene encodes a monoglyceride lipase, which catalyzes the hydrolysis of monoglycerides into fatty acids and glycerol.

Monoglyceride Lipase

Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842).

Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842).

Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333).

Acylglycerol catabolic process Source: UniProtKB
Arachidonic acid metabolic process Source: UniProtKB
Fatty acid biosynthetic process Source: UniProtKB-KW
Inflammatory response Source: ProtInc
Lipid metabolic process Source: ProtInc
Monoacylglycerol catabolic process Source: UniProtKB
Regulation of endocannabinoid signaling pathway Source: UniProtKB
Regulation of inflammatory response Source: UniProtKB
Regulation of sensory perception of pain Source: UniProtKB
Regulation of signal transduction Source: UniProtKB
Triglyceride catabolic process Source: UniProtKB-UniPathway

Cytosol
Other locations
Membrane