MGLL
This gene encodes a monoglyceride lipase, which catalyzes the hydrolysis of monoglycerides into fatty acids and glycerol.
Full Name
Monoglyceride Lipase
Function
Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842).
Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842).
Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333).
Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842).
Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333).
Biological Process
Acylglycerol catabolic process Source: UniProtKB
Arachidonic acid metabolic process Source: UniProtKB
Fatty acid biosynthetic process Source: UniProtKB-KW
Inflammatory response Source: ProtInc
Lipid metabolic process Source: ProtInc
Monoacylglycerol catabolic process Source: UniProtKB
Regulation of endocannabinoid signaling pathway Source: UniProtKB
Regulation of inflammatory response Source: UniProtKB
Regulation of sensory perception of pain Source: UniProtKB
Regulation of signal transduction Source: UniProtKB
Triglyceride catabolic process Source: UniProtKB-UniPathway
Arachidonic acid metabolic process Source: UniProtKB
Fatty acid biosynthetic process Source: UniProtKB-KW
Inflammatory response Source: ProtInc
Lipid metabolic process Source: ProtInc
Monoacylglycerol catabolic process Source: UniProtKB
Regulation of endocannabinoid signaling pathway Source: UniProtKB
Regulation of inflammatory response Source: UniProtKB
Regulation of sensory perception of pain Source: UniProtKB
Regulation of signal transduction Source: UniProtKB
Triglyceride catabolic process Source: UniProtKB-UniPathway
Cellular Location
Cytosol
Other locations
Membrane
Other locations
Membrane
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Anti-MGLL antibodies
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Target: MGLL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYA-0041
Application*: F, C, FN, P
Target: MGLL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYM-2180
Application*: F, FN, C
Target: MGLL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-2179
Application*: F, IF, IH, WB
Target: MGLL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2178
Application*: F, IF, IH, WB
Target: MGLL
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2177
Application*: F, P, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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