Mouse Anti-MMUT Recombinant Antibody (
3G12D12) (V2LY-0725-LY167)

Name: Mouse Anti-MMUT Recombinant Antibody (3G12D12)
SKU: V2LY-0725-LY167
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-MMUT Recombinant Antibody (3G12D12) (V2LY-0725-LY167) in WB

Western Blot Positive WB detected in: MMUT antibody at 1:1000 Lane 1: Mouse liver tissue Lane 2: Rat kidney tissue Lane 3: Rat heart tissue Secondary Goat polyclonal to Mouse IgG at 1/20000 dilution Predicted band size: 83 KDa Observed band size: 83 KDa Exposure time: 5min

Mouse Anti-MMUT Recombinant Antibody (3G12D12) (V2LY-0725-LY167) in WB

Western Blot Positive WB detected in: MMUT antibody at 1:1000 Lane 1: U87 whole cell lysate Lane 2: U251 whole cell lysate Lane 3: Jurkat whole cell lysate Lane 4: K562 whole cell lysate Lane 5: 293 whole cell lysate Secondary Goat polyclonal to Mouse IgG at 1/20000 dilution Predicted band size: 83 KDa Observed band size: 83 KDa Exposure time: 5min

Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

3G12D12

Application

ELISA, WB

Immunogen

Recombinant Human Methylmalonyl-CoA mutase, mitochondrial protein (31-748AA).

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, Glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

methylmalonyl-CoA mutase

Entrez Gene ID

4594

UniProt ID

P22033

Alternative Names

MCM; MUT

Function

Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

Biological Process

Homocysteine metabolic process
Positive regulation of GTPase activity
Post-embryonic development
Propionate metabolic process, methylmalonyl pathway
Succinyl-CoA biosynthetic process

Cellular Location

Mitochondrion matrix
Mitochondrion
Cytoplasm

Involvement in disease

Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency (MAMM):
An often fatal disorder of organic acid metabolism. Common clinical features include lethargy, vomiting, failure to thrive, hypotonia, neurological deficit and early death. Two forms of the disease are distinguished by the presence (mut-) or absence (mut0) of residual enzyme activity. Mut0 patients have more severe neurological manifestations of the disease than do MUT- patients. MAMM is unresponsive to vitamin B12 therapy.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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