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Mouse Anti-MREG Recombinant Antibody (CBFYM-0718) (CBMAB-M0860-FY)

This product is mouse antibody that recognizes MREG. The antibody CBFYM-0718 can be used for immunoassay techniques such as: ELISA, IP, WB.
See all MREG antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0718
Antibody Isotype
IgG1, k
Application
ELISA, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Melanoregulin
Introduction
MREG is required for lysosome maturation and support a role for MREG in intracellular trafficking.
Entrez Gene ID
55686
UniProt ID
Q8N565
Alternative Names
Melanoregulin; Dilute Suppressor Protein Homolog; DSU; Whn-Dependent Transcript 2; WDT2
Function
Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes. Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (By similarity).

Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024).

Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity).
Biological Process
Melanocyte differentiation Source: GO_Central
Melanosome localization Source: UniProtKB
Melanosome transport Source: GO_Central
Minus-end-directed organelle transport along microtubule Source: Ensembl
Phagosome maturation Source: UniProtKB
Cellular Location
Lysosome
Lysosome membrane
Plasma membrane
Apical cell membrane
Other locations
Melanosome membrane
Cytoplasmic vesicle membrane
Note: Localizes to the inner segment and basal outer segment of rods in the retina.
PTM
Palmitoylated. Palmitoylation is required to maintain the protein at the melanosome membrane.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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