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Mouse Anti-MTAP Recombinant Antibody (2G4) (CBMAB-A5654-LY)

The product is antibody recognizes MTAP. The antibody 2G4 immunoassay techniques such as: WB, ELISA.
See all MTAP antibodies
Published Data
Fig. 1 Corresponding methylthioadenosine phosphorylase (MTAP) immunohistochemistry (IHC).
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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
2G4
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
MTAP (AAH18625, 1 a.a. ~ 154 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
methylthioadenosine phosphorylase
Introduction
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq]
Entrez Gene ID
Human4507
Mouse66902
Rat298227
UniProt ID
HumanQ13126
MouseQ9CQ65
RatQ7TP15
Alternative Names
MSAP; c86fus
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Biological Process
L-methionine salvage from methylthioadenosine Source: GO_Central
Nucleobase-containing compound metabolic process Source: ProtInc
Purine ribonucleoside salvage Source: UniProtKB-KW
Response to testosterone Source: Ensembl
Cellular Location
Nucleus
Cytoplasm
Involvement in disease
Diaphyseal medullary stenosis with malignant fibrous histiocytoma (DMSMFH):
An autosomal dominant bone dysplasia characterized by pathologic fractures due to abnormal cortical growth and diaphyseal medullary stenosis. The fractures heal poorly, and there is progressive bowing of the lower extremities. Some patients show a limb-girdle myopathy, with muscle weakness and atrophy. Approximately 35% of affected individuals develop an aggressive form of bone sarcoma consistent with malignant fibrous histiocytoma or osteosarcoma.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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