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Mouse Anti-NAB2 Recombinant Antibody (6D10) (CBMAB-N1050-WJ)

This product is a Mouse antibody that recognizes NAB2. The antibody 6D10 can be used for immunoassay techniques such as: WB.
See all NAB2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6D10
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NAB2
Introduction
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Entrez Gene ID
4665
UniProt ID
Q15742
Alternative Names
NGFI-A Binding Protein 2; Melanoma-Associated Delayed Early Response Protein; EGR1 Binding Protein 2; MADER; NGFI-A Binding Protein 2 (EGR1 Binding Protein 2); NGFI-A-Binding Protein 2; EGR-1-Binding Protein 2; Protein MADER;
Function
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).
Biological Process
Endochondral ossification Source: Ensembl
Myelination Source: Ensembl
Negative regulation of transcription by RNA polymerase III Source: MGI
Positive regulation of tau-protein kinase activity Source: ARUK-UCL
Regulation of epidermis development Source: Ensembl
Regulation of transcription, DNA-templated Source: GO_Central
Schwann cell differentiation Source: Ensembl
Cellular Location
Nucleus
Note: Isoform 2 is not localized to the nucleus.
PTM
Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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