NAB2

This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq]
Full Name
NAB2
Function
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).
Biological Process
Endochondral ossification Source: Ensembl
Myelination Source: Ensembl
Negative regulation of transcription by RNA polymerase III Source: MGI
Positive regulation of tau-protein kinase activity Source: ARUK-UCL
Regulation of epidermis development Source: Ensembl
Regulation of transcription, DNA-templated Source: GO_Central
Schwann cell differentiation Source: Ensembl
Cellular Location
Nucleus
Note: Isoform 2 is not localized to the nucleus.
PTM
Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain.
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Anti-NAB2 antibodies

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Mouse Anti-NAB2 Antibody (2G1) (CBMAB-0696-YC)

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Target: NAB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2G1
Application*: IP, WB, M
Datasheet SDS

Mouse Anti-NAB2 Recombinant Antibody (6D10) (CBMAB-N1050-WJ)

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Target: NAB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D10
Application*: WB
Datasheet SDS

Mouse Anti-NAB2 Recombinant Antibody (5D10) (CBMAB-N1048-WJ)

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Target: NAB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5D10
Application*: WB
Datasheet SDS

Mouse Anti-NAB2 Recombinant Antibody (4H6) (CBMAB-N1047-WJ)

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Target: NAB2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4H6
Application*: E, WB
Datasheet SDS

Mouse Anti-NAB2 Recombinant Antibody (3H5) (CBMAB-N1046-WJ)

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Target: NAB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H5
Application*: P, WB
Datasheet SDS

Mouse Anti-NAB2 Recombinant Antibody (1C4) (CBMAB-N1043-WJ)

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Target: NAB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C4
Application*: WB
Datasheet SDS

Mouse Anti-NAB2 Recombinant Antibody (1B10) (CBMAB-N1042-WJ)

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Target: NAB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1B10
Application*: WB
Datasheet SDS

Mouse Anti-NAB2 Recombinant Antibody (1E12) (CBMAB-N1041-WJ)

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Target: NAB2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1E12
Application*: P, WB
Datasheet SDS

Mouse Anti-NAB2 Recombinant Antibody (1E1) (CBMAB-N1040-WJ)

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Target: NAB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E1
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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