Mouse Anti-NCOR2 Recombinant Antibody (CBXS-3669) (CBMAB-S0948-CQ)

Name: Mouse Anti-NCOR2 Recombinant Antibody (CBXS-3669)
SKU: CBMAB-S0948-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-3669

Application

IF, IHC-Fr, IP, WB, ChIP

Immunogen

A synthetic peptide from the human SMRT protein corresponding to amino acids 994-1005 (ASASDPHREKTQ) coupled to KLH

Specificity

Human, Monkey

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Nuclear Receptor Corepressor 2

Introduction

This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.

Entrez Gene ID

Human	9612
Monkey	706261

UniProt ID

Human	Q9Y618
Monkey	F7GMR8

Alternative Names

Nuclear Receptor Corepressor 2; Thyroid-, Retinoic-Acid-Receptor-Associated Corepressor; T3 Receptor-Associating Factor; CTG Repeat Protein 26; SMAP270; N-CoR2; CTG26; SMRT; TRAC;

Function

Transcriptional corepressor (PubMed:20812024).

Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).

Biological Process

Estrous cycle Source: Ensembl
Lactation Source: Ensembl
Negative regulation of androgen receptor signaling pathway Source: UniProtKB
Negative regulation of production of miRNAs involved in gene silencing by miRNA Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: MGI
Regulation of cellular ketone metabolic process Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to estradiol Source: Ensembl
Response to organonitrogen compound Source: Ensembl

Paluvai, H., Shanmukha, K. D., Tyedmers, J., & Backs, J. (2023). Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseases. Frontiers in Molecular Biosciences, 10.

Patton, A., Ilaslan, H., Armstrong, S. M., Bakhshwin, A., Cheng, Y. W., Minhas, F., & Fritchie, K. J. (2023). Keratin-positive giant cell-rich tumor of bone harboring an HMGA2:: NCOR2 fusion: two cases, including a patient with metastatic disease, and review of the literature. International Journal of Surgical Pathology, 10668969231185076.

Tsai, K. K., Huang, S. S., Northey, J. J., Liao, W. Y., Hsu, C. C., Cheng, L. H., ... & Weaver, V. M. (2022). Screening of organoids derived from patients with breast cancer implicates the repressor NCOR2 in cytotoxic stress response and antitumor immunity. Nature Cancer, 3(6), 734-752.

Panagopoulos, I., Andersen, K., Gorunova, L., Lund-Iversen, M., Lobmaier, I., & Heim, S. (2022). Recurrent fusion of the genes for high-mobility group AT-hook 2 (HMGA2) and nuclear receptor co-repressor 2 (NCOR2) in osteoclastic giant cell-rich tumors of bone. Cancer Genomics & Proteomics, 19(2), 163-177.

Mori, T., Verma, R., Nakamoto-Matsubara, R., Siu, K. T., Panaroni, C., Fulzele, K. S., ... & Raje, N. S. (2021). Low NCOR2 levels in multiple myeloma patients drive multidrug resistance via MYC upregulation. Blood Cancer Journal, 11(12), 194.

Long, M. D., Jacobi, J. J., Singh, P. K., Llimos, G., Wani, S. A., Rowsam, A. M., ... & Smiraglia, D. J. (2021). Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer. Cell reports, 37(11).

Agaimy, A., Michal, M., Stoehr, R., Ferrazzi, F., Fabian, P., Michal, M., ... & Kösemehmetoğlu, K. (2021). Recurrent novel HMGA2-NCOR2 fusions characterize a subset of keratin-positive giant cell-rich soft tissue tumors. Modern Pathology, 34(8), 1507-1520.

Luan, S., Fu, P., Wang, X., Gao, Y., Shi, K., & Guo, Y. (2020). Circular RNA circ-NCOR2 accelerates papillary thyroid cancer progression by sponging miR-516a-5p to upregulate metastasis-associated protein 2 expression. Journal of International Medical Research, 48(9), 0300060520934659.

Wu, Y., Zhou, Y., Huan, L., Xu, L., Shen, M., Huang, S., & Liang, L. (2019). LncRNA MIR22HG inhibits growth, migration and invasion through regulating the miR‐10a‐5p/NCOR2 axis in hepatocellular carcinoma cells. Cancer science, 110(3), 973-984.

Zhou, W., He, Y., Rehman, A. U., Kong, Y., Hong, S., Ding, G., ... & Sun, Z. (2019). Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus–CA3 projection. Nature neuroscience, 22(2), 205-217.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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