NCOR2

This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
Full Name
Nuclear Receptor Corepressor 2
Function
Transcriptional corepressor (PubMed:20812024).

Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).
Biological Process
Estrous cycle Source: Ensembl
Lactation Source: Ensembl
Negative regulation of androgen receptor signaling pathway Source: UniProtKB
Negative regulation of production of miRNAs involved in gene silencing by miRNA Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: MGI
Regulation of cellular ketone metabolic process Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to estradiol Source: Ensembl
Response to organonitrogen compound Source: Ensembl
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Anti-NCOR2 antibodies

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Rabbit Anti-NCOR2 Recombinant Antibody (D8D2L) (CBMAB-CP3095-LY)

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Target: NCOR2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D8D2L
Application*: WB, CI
Datasheet SDS

Recombinant Mouse Anti-NCOR2 Recombinant Antibody (1E7) (CBMAB-XB0871-YC)

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Target: NCOR2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E7
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-NCOR2 Recombinant Antibody (CBXS-3362) (CBMAB-S6099-CQ)

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Target: NCOR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3362
Application*: IH, WB
Datasheet SDS

Rabbit Anti-NCOR2 Recombinant Antibody (CBXS-0050) (CBMAB-S3051-CQ)

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Target: NCOR2
Host: Rabbit
Specificity: Human, Monkey
Clone: CBXS-0050
Application*: WB, CI
Datasheet SDS

Mouse Anti-NCOR2 Recombinant Antibody (CBXS-3734) (CBMAB-S1009-CQ)

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Target: NCOR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3734
Application*: IP, WB
Datasheet SDS

Mouse Anti-NCOR2 Recombinant Antibody (CBXS-3669) (CBMAB-S0948-CQ)

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Target: NCOR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBXS-3669
Application*: IF, C, IP, WB, CI
Datasheet SDS

Mouse Anti-NCOR2 Recombinant Antibody (M10H6) (CBMAB-N1475-WJ)

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Target: NCOR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: M10H6
Application*: CI, C, IP, WB
Datasheet SDS

Mouse Anti-NCOR2 Recombinant Antibody (H7) (CBMAB-N1474-WJ)

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Target: NCOR2
Host: Mouse
Specificity: Human
Clone: H7
Application*: WB, IP
Datasheet SDS

Mouse Anti-NCOR2 Recombinant Antibody (CBWJN-0471) (CBMAB-N1473-WJ)

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Target: NCOR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0471
Application*: IH, WB
Datasheet SDS

Mouse Anti-NCOR2 Recombinant Antibody (CBWJN-1223) (CBMAB-N1472-WJ)

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Target: NCOR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBWJN-1223
Application*: WB, CI, IH, C
Datasheet SDS

Mouse Anti-NCOR2 Recombinant Antibody (CBWJN-1222) (CBMAB-N1471-WJ)

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Target: NCOR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1222
Application*: WB, IH, IF, P
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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