Rabbit Anti-NLGN3 Recombinant Antibody (CBWJN-1427) (CBMAB-N2643-WJ)

Name: Rabbit Anti-NLGN3 Recombinant Antibody (CBWJN-1427)
SKU: CBMAB-N2643-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBWJN-1427

Application

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Neuroligin 3

Introduction

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009]

Entrez Gene ID

54413

UniProt ID

Q9NZ94

Alternative Names

Neuroligin 3; Gliotactin Homolog; Neuroligin-3; KIAA1480; HNL3; NL3;

Function

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity).

Biological Process

Adult behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Axon extensionISS:BHF-UCL
Chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Inhibitory postsynaptic potentialISS:BHF-UCL
LearningManual Assertion Based On ExperimentIMP:BHF-UCL
Modulation of chemical synaptic transmissionISS:BHF-UCL
Neuron cell-cell adhesionISS:BHF-UCL
Positive regulation of AMPA receptor activityISS:BHF-UCL
Positive regulation of excitatory postsynaptic potentialISS:BHF-UCL
Positive regulation of synapse assemblyISS:BHF-UCL
Positive regulation of synaptic transmission, glutamatergicISS:BHF-UCL
Postsynaptic membrane assemblyISS:BHF-UCL
Presynapse assemblyManual Assertion Based On ExperimentTAS:ARUK-UCL
Presynaptic membrane assemblyISS:BHF-UCL
Receptor-mediated endocytosisISS:BHF-UCL
Regulation of respiratory gaseous exchange by nervous system processISS:BHF-UCL
Rhythmic synaptic transmissionISS:BHF-UCL
Social behaviorManual Assertion Based On ExperimentIMP:UniProtKB
Synapse assemblyISS:BHF-UCL
Synapse organizationManual Assertion Based On ExperimentIMP:UniProtKB
Synaptic vesicle endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Vocalization behaviorManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

Cell membrane
Cell junction, synapse
Detected at both glutamatergic and GABAergic synapses.

Involvement in disease

Autism, X-linked 1 (AUTSX1):
A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.
Asperger syndrome, X-linked, 1 (ASPGX1):
A syndrome with features similar to autism. Affected individuals exhibit qualitative impairment in social interaction, as manifest by impairment in the use of non-verbal behaviors such as eye-to-eye gaze, facial expression, body postures, and gestures, failure to develop appropriate peer relationships, and lack of social sharing or reciprocity. Patients also exhibit restricted, repetitive and stereotyped patterns of behavior, interests, and activities, including abnormal preoccupation with certain activities and inflexible adherence to routines or rituals. Asperger syndrome is primarily distinguished from autism by the higher cognitive abilities and a more normal and timely development of language and communicative phrases.

Topology

Extracellular: 38-709
Helical: 710-730
Cytoplasmic: 731-848

Jeong, J., Han, W., Hong, E., Pandey, S., Li, Y., Lu, W., & Roche, K. W. (2023). Regulation of NLGN3 and the synaptic Rho-GEF signaling pathway by CDK5. Journal of Neuroscience, 43(44), 7264-7275.

Yun, E. J., Kim, D., Kim, S., Hsieh, J. T., & Baek, S. T. (2023). Targeting Wnt/β-catenin-mediated upregulation of oncogenic NLGN3 suppresses cancer stem cells in glioblastoma. Cell Death & Disease, 14(7), 423.

Ramirez, M. A., Ninoyu, Y., Miller, C., Andrade, L. R., Edassery, S., Bomba-Warczak, E., ... & Savas, J. N. (2022). Cochlear ribbon synapse maturation requires Nlgn1 and Nlgn3. IScience, 25(8).

Sledziowska, M., Galloway, J., & Baudouin, S. J. (2020). Evidence for a contribution of the Nlgn3/Cyfip1/Fmr1 pathway in the pathophysiology of autism spectrum disorders. Neuroscience, 445, 31-41.

Li, Z., Gao, W., Fei, Y., Gao, P., Xie, Q., Xie, J., & Xu, Z. (2019). NLGN3 promotes neuroblastoma cell proliferation and growth through activating PI3K/AKT pathway. European Journal of Pharmacology, 857, 172423.

Quartier, A., Courraud, J., Thi Ha, T., McGillivray, G., Isidor, B., Rose, K., ... & Piton, A. (2019). Novel mutations in NLGN3 causing autism spectrum disorder and cognitive impairment. Human mutation, 40(11), 2021-2032.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
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For research use only. Not intended for any clinical use.

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