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Mouse Anti-ORC4 Recombinant Antibody (CBXO-0327) (CBMAB-O0542-CQ)

This product is a mouse antibody that recognizes ORC4. The antibody CBXO-0327 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all ORC4 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXO-0327
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
origin recognition complex, subunit 4
Introduction
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene.
Entrez Gene ID
Human5000
Mouse26428
Rat295596
UniProt ID
HumanO43929
MouseO88708
RatQ6P9Z8
Alternative Names
Origin Recognition Complex Subunit 4; ORC4L; Origin Recognition Complex, Subunit 4 Homolog (S. Cerevisiae); Origin Recognition Complex, Subunit 4 (Yeast Homolog)-Like; Origin Recognition Complex, Subunit 4-Like (S. Cerevisiae); Origin Recognition Complex, Subunit 4-Like (Yeast); Origin Recognition Complex, Subunit 4 Homolog; Origin Recognition Complex, Subunit 4; ORC4P
Function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Biological Process
DNA replication initiationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Involvement in disease
Meier-Gorlin syndrome 2 (MGORS2):
A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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