Rabbit Anti-OTX2 Recombinant Antibody (CBXO-0138) (CBMAB-O0739-CQ)

Name: Rabbit Anti-OTX2 Recombinant Antibody (CBXO-0138)
SKU: CBMAB-O0739-CQ
Rating: 5 (1 reviews)

See all OTX2 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXO-0138

Application

Immunogen

A synthetic peptide corresponding to residues in human OTX2

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS 49%, Glycerol 50%, BSA 0.05%

Preservative

0.01% Sodium Azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Orthodenticle Homeobox 2

Introduction

This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine.

Entrez Gene ID

5015

UniProt ID

P32243

Alternative Names

Orthodenticle Homeobox 2; Orthodenticle Homolog 2; Orthodenticle Homolog 2 (Drosophila); Homeobox Protein OTX2; MCOPS5; CPHD6

Function

Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'.

Biological Process

Axon guidanceManual Assertion Based On ExperimentIDA:UniProtKB
Dopaminergic neuron differentiationManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Forebrain developmentManual Assertion Based On ExperimentTAS:UniProtKB
Midbrain developmentManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of embryonic developmentISS:UniProtKB
Positive regulation of gastrulationISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Primitive streak formationISS:UniProtKB
Protein-containing complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of smoothened signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Involvement in disease

Microphthalmia, syndromic, 5 (MCOPS5):
Patients manifest unilateral or bilateral microphthalmia/clinical anophthalmia and variable additional features including pituitary dysfunction, coloboma, microcornea, cataract, retinal dystrophy, hypoplasia or agenesis of the optic nerve, agenesis of the corpus callosum, developmental delay, joint laxity, hypotonia, and seizures. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.
Pituitary hormone deficiency, combined, 6 (CPHD6):
Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. CPHD6 patients manifest neonatal hypoglycemia, and deficiencies of growth hormone, thyroid-stimulating hormone, luteinizing hormone, follicle stimulating hormone and adrenocorticotropic hormone.
Retinal dystrophy, early-onset, with or without pituitary dysfunction (RDEOP):
An autosomal dominant ocular disease characterized by pattern dystrophy of the retinal pigment epithelium, and photoreceptor degeneration. Mild developmental anomalies include optic nerve head dysplasia, microcornea, and Rathke's cleft cyst. Some patients manifest pituitary dysfunction.

Park, J. W., Lee, E. J., Moon, E., Kim, H. L., Kim, I. B., Hodzic, D., ... & Kim, J. W. (2023). Orthodenticle homeobox 2 is transported to lysosomes by nuclear budding vesicles. Nature communications, 14(1), 1111.

Araújo, C., Baptista, C., & Paiva, I. (2023). An Orthodenticle Homeobox 2 (OTX2) Mutation in a Patient With Combined Pituitary Hormone Deficiency, Pituitary Malformation, and Retinitis Pigmentosa. Cureus, 15(12).

Fabiani, M., Libotte, F., Margiotti, K., Tannous, D. K. I., Sparacino, D., D’Aleo, M. P., ... & Giorlandino, C. (2022). Agnathia-otocephaly complex due to a de novo deletion in the OTX2 gene. Genes, 13(12), 2269.

Matsumoto, R., Suga, H., Aoi, T., Bando, H., Fukuoka, H., Iguchi, G., ... & Takahashi, Y. (2020). Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells. The Journal of Clinical Investigation, 130(2), 641-654.

Chan, C. S., Lonfat, N., Zhao, R., Davis, A. E., Li, L., Wu, M. R., ... & Wang, S. (2020). Cell type-and stage-specific expression of Otx2 is regulated by multiple transcription factors and cis-regulatory modules in the retina. Development, 147(14), dev187922.

Rohde, K., Hertz, H., & Rath, M. F. (2019). Homeobox genes in melatonin‐producing pinealocytes: Otx2 and Crx act to promote hormone synthesis in the mature rat pineal gland. Journal of pineal research, 66(4), e12567.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Rabbit Anti-OTX2 Recombinant Antibody (CBXO-0138)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-OTX2 Recombinant Antibody (BA0193) (CAT#: CBMAB-0562CQ)

Mouse Anti-OTX2 Antibody (1F7) (CAT#: CBMAB-0773-YC)

Mouse Anti-OTX2 Recombinant Antibody (CBT962) (CAT#: V2LY-0625-LY3144)

Mouse Anti-OTX2 Recombinant Antibody (CBXO-0328) (CAT#: CBMAB-O0738-CQ)

Mouse Anti-OTX2 Recombinant Antibody (1H12C4B5) (CAT#: CBMAB-0564CQ)

Rabbit Anti-OTX2 Recombinant Antibody (D7Y3J) (CAT#: CBMAB-CP1814-LY)

Mouse Anti-OTX2 Recombinant Antibody (CBXO-0443) (CAT#: CBMAB-O0745-CQ)

Rabbit Anti-OTX2 Recombinant Antibody (CBXO-0425) (CAT#: CBMAB-O0737-CQ)

Rabbit Anti-OTX2 (AA 20-39, 276-289) Recombinant Antibody (CBXO-0448) (CAT#: CBMAB-O0735-CQ)

Rabbit Anti-OTX2 Recombinant Antibody (14H14L5) (CAT#: CBMAB-0563CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry