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Mouse Anti-PAFAH1B3 Recombinant Antibody (2D3) (CBMAB-P0659-YC)

Provided herein is a Mouse monoclonal antibody against Human Platelet Activating Factor Acetylhydrolase 1b Catalytic Subunit 3. The antibody can be used for immunoassay techniques, such as WB.
See all PAFAH1B3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D3
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa
Introduction
PAFAH1B3 is an acetylhydrolase that catalyzes the removal of an acetyl group from the glycerol backbone of platelet-activating factor. The encoded enzyme is a subunit of the platelet-activating factor acetylhydrolase isoform 1B complex, which consists of the catalytic beta and gamma subunits and the regulatory alpha subunit. This complex functions in brain development. A translocation between this gene on chromosome 19 and the CDC-like kinase 2 gene on chromosome 1 has been observed, and was associated with cognitive disability, ataxia, and atrophy of the brain. Alternatively spliced transcript variants have been described.
Entrez Gene ID
5050
UniProt ID
Q15102
Alternative Names
Platelet Activating Factor Acetylhydrolase 1b Catalytic Subunit 3; Platelet-Activating Factor Acetylhydrolase 1b, Catalytic Subunit 3 (29kDa); Platelet-Activating Factor Acetylhydrolase, Isoform Ib, Subunit 3 (29kDa); PAF Acetylhydrolase 29 KDa Subunit; PAF-AH1b Alpha 1 Subunit; PAF-AH 29 KDa Subunit; PAF-AH Subunit Gamma;
Function
Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain.
Biological Process
Brain developmentManual Assertion Based On ExperimentIBA:GO_Central
Lipid catabolic processIEA:UniProtKB-KW
Lipid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
SpermatogenesisIEA:Ensembl
Cellular Location
Cytoplasm

Jiang, W., Quan, R., Bhandari, A., Hirachan, S., Chen, C., Lv, S., & Zheng, C. (2024). PAFAH1B3 regulates papillary thyroid carcinoma cell proliferation and metastasis by affecting the EMT. Current Medicinal Chemistry, 31(9), 1152-1164.

Zhang, G. (2023). Increased PAFAH1B3 was associated with poor prognosis and T-cell exhaustion microenvironment in hepatocellular carcinoma. Discover Oncology, 14(1), 227.

Dong, C., Yao, J., Wu, Z., Hu, J., Sun, L., Wu, Z., ... & Yin, X. (2023). PAFAH1B3 is a KLF9 target gene and promotes proliferation and metastasis in pancreatic cancer.

Tang, S., Ni, J., Chen, B., Sun, F., Huang, J., Ni, S., & Tang, Z. (2022). PAFAH1B3 predicts poor prognosis and promotes progression in lung adenocarcinoma. BMC cancer, 22(1), 525.

Xie, T., Guo, X., Wu, D., Li, S., Lu, Y., Wang, X., & Chen, L. (2021). PAFAH1B3 expression is correlated with gastric cancer cell proliferation and immune infiltration. Frontiers in Oncology, 11, 591545.

Xu, W., Lu, X., Liu, J., Chen, Q., Huang, X., Huang, K., ... & Zhang, X. (2021). Identification of PAFAH1B3 as candidate prognosis marker and potential therapeutic target for hepatocellular carcinoma. Frontiers in Oncology, 11, 700700.

Fan, J., Yang, Y., Qian, J. K., Zhang, X., Ji, J. Q., Zhang, L., ... & Yuan, F. (2021). Aberrant expression of PAFAH1B3 affects proliferation and apoptosis in osteosarcoma. Frontiers in Oncology, 11, 664478.

Zhang, G. (2021). Identification of a Novel Prognostic Classifier for Platelet-related Genes Characteristics and Prognostic Significance of Aberrant Expression of PAFAH1B3 in Hepatocellular Carcinoma.

Xu, J., Zang, Y., Cao, S., Lei, D., & Pan, X. (2019). Aberrant expression of PAFAH1B3 associates with poor prognosis and affects proliferation and aggressiveness in hypopharyngeal squamous cell carcinoma. OncoTargets and therapy, 2799-2808.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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