PAFAH1B3

This gene encodes an acetylhydrolase that catalyzes the removal of an acetyl group from the glycerol backbone of platelet-activating factor. The encoded enzyme is a subunit of the platelet-activating factor acetylhydrolase isoform 1B complex, which consists of the catalytic beta and gamma subunits and the regulatory alpha subunit. This complex functions in brain development. A translocation between this gene on chromosome 19 and the CDC-like kinase 2 gene on chromosome 1 has been observed, and was associated with mental retardation, ataxia, and atrophy of the brain. Alternatively spliced transcript variants have been described. [provided by RefSeq]
Full Name
platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa
Function
Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain.
Biological Process
Brain developmentManual Assertion Based On ExperimentIBA:GO_Central
Lipid catabolic processIEA:UniProtKB-KW
Lipid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
SpermatogenesisIEA:Ensembl
Cellular Location
Cytoplasm
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Anti-PAFAH1B3 antibodies

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Mouse Anti-PAFAH1B3 Recombinant Antibody (CBYC-P135) (CBMAB-P0665-YC)

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Target: PAFAH1B3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBYC-P135
Application*: E, WB
Datasheet SDS

Mouse Anti-PAFAH1B3 Recombinant Antibody (CBYC-P134) (CBMAB-P0664-YC)

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Target: PAFAH1B3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-P134
Application*: E, IC, WB
Datasheet SDS

Mouse Anti-PAFAH1B3 Recombinant Antibody (9G415) (CBMAB-P0663-YC)

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Target: PAFAH1B3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 9G415
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-PAFAH1B3 Recombinant Antibody (8C11) (CBMAB-P0662-YC)

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Target: PAFAH1B3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: 8C11
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-PAFAH1B3 Recombinant Antibody (5D2) (CBMAB-P0661-YC)

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Target: PAFAH1B3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5D2
Application*: WB, IH
Datasheet SDS

Mouse Anti-PAFAH1B3 Recombinant Antibody (3G6) (CBMAB-P0660-YC)

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Target: PAFAH1B3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3G6
Application*: E, WB
Datasheet SDS

Mouse Anti-PAFAH1B3 Recombinant Antibody (2D3) (CBMAB-P0659-YC)

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Target: PAFAH1B3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2D3
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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