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Mouse Anti-PCSK1 Recombinant Antibody (2G12) (CBMAB-P1092-YC)

Provided herein is a Mouse monoclonal antibody against Human Proprotein Convertase Subtilisin/Kexin Type 1. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PCSK1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G12
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
PCSK1 (NP_000430, 652-753 aa) partial recombinant protein with GST tag. Immunogen sequence: GGRRDELEEG APSEAMLRLL QSAFSKNSPP KQSPKKSPTA KLNIPYENFY EALEKLNKPS QLKDSEDSLY NDYVDVFYNT KPYKHRDDRL LQALVDILNE EN
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 652-753

Target

Full Name
proprotein convertase subtilisin/kexin type 1
Introduction
PCSK1 is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene
Entrez Gene ID
5122
UniProt ID
P29120
Alternative Names
Proprotein Convertase Subtilisin/Kexin Type 1; Prohormone Convertase 1; Neuroendocrine Convertase 1; Prohormone Convertase 3; Proprotein Convertase 1; EC 3.4.21.93; NEC1;
Function
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
Biological Process
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
NeurogenesisIEA:Ensembl
Pancreas developmentIEA:Ensembl
Peptide biosynthetic processISS:BHF-UCL
Peptide hormone processingManual Assertion Based On ExperimentIBA:GO_Central
Pituitary gland developmentIEA:Ensembl
Positive regulation of protein secretionIEA:Ensembl
Protein autoprocessingIEA:Ensembl
Protein processingManual Assertion Based On ExperimentIBA:GO_Central
ProteolysisManual Assertion Based On ExperimentTAS:ProtInc
Response to axon injuryIEA:Ensembl
Response to calcium ionIEA:Ensembl
Response to chlorateIEA:Ensembl
Response to fatty acidIEA:Ensembl
Response to glucocorticoidIEA:Ensembl
Response to glucoseIEA:Ensembl
Response to interleukin-1IEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Response to morphineIEA:Ensembl
Response to nutrient levelsIEA:Ensembl
Response to peptide hormoneIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Cellular Location
Cytoplasmic vesicle, secretory vesicle
Localized in the secretion granules.
Involvement in disease
Proprotein convertase 1 deficiency (PC1 deficiency):
Characterized by obesity, hypogonadism, hypoadrenalism, reactive hypoglycemia as well as marked small-intestinal absorptive dysfunction It is due to impaired processing of prohormones.
PTM
O-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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