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Mouse Anti-PDHB Recombinant Antibody (17A5E2H8) (CBMAB-P1284-YC)

Provided herein is a Mouse monoclonal antibody against Human Pyruvate Dehydrogenase E1 Beta Subunit. The antibody can be used for immunoassay techniques, such as WB, IHC-P.
See all PDHB antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Cattle
Clone
17A5E2H8
Antibody Isotype
IgG1
Application
WB, IHC-P

Basic Information

Specificity
Human, Mouse, Rat, Cattle
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
pyruvate dehydrogenase (lipoamide) beta
Introduction
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency.
Entrez Gene ID
Human5162
Mouse68263
Rat289950
Cattle613610
UniProt ID
HumanP11177
MouseQ9D051
RatP49432
CattleP11966
Alternative Names
2610103L06Rik; AL024199; C81408
Function
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2, and thereby links the glycolytic pathway to the tricarboxylic cycle.
Biological Process
Acetyl-CoA biosynthetic process from pyruvateManual Assertion Based On ExperimentIDA:UniProtKB
Glucose metabolic processIEA:UniProtKB-KW
Mitochondrial acetyl-CoA biosynthetic process from pyruvate1 PublicationIC:MGI
Tricarboxylic acid cycleManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Mitochondrion matrix
Involvement in disease
Pyruvate dehydrogenase E1-beta deficiency (PDHBD):
An enzymatic defect causing primary lactic acidosis in children. It is associated with a broad clinical spectrum ranging from fatal lactic acidosis in the newborn to chronic neurologic dysfunction with structural abnormalities in the central nervous system without systemic acidosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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