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Mouse Anti-PIWIL3 Recombinant Antibody (C-3) (CBMAB-P1909-YC)

Provided herein is a Mouse monoclonal antibody against Human Piwi like RNA-mediated gene silencing 3. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all PIWIL3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
C-3
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Piwi Like RNA-mediated Gene Silencing 3
Introduction
PIWIL3 is a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells.
Entrez Gene ID
440822
UniProt ID
Q7Z3Z3
Alternative Names
HIWI3
Function
May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).
Biological Process
Cell differentiationIEA:UniProtKB-KW
Gene silencing by RNAManual Assertion Based On ExperimentIBA:GO_Central
Meiotic cell cycleIEA:UniProtKB-KW
Regulation of translationIEA:UniProtKB-KW
SpermatogenesisIEA:UniProtKB-KW
Cellular Location
Cytoplasm
Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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