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Mouse Anti-PNMT Recombinant Antibody (3G4) (CBMAB-P2267-YC)

Provided herein is a Mouse monoclonal antibody against Human Phenylethanolamine N-Methyltransferase. The antibody can be used for immunoassay techniques, such as ELISA, IP.
See all PNMT antibodies
Published Data
Fig.1 Average densitometric quantitative analysis (left panel) and representative Western blot (right panel) from blots showing the ratio of TH and PNMT to Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in SCAT and EAT.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3G4
Antibody Isotype
IgG2b, κ
Application
ELISA, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PNMT
Introduction
PNMT catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production.
Entrez Gene ID
5409
UniProt ID
P11086
Alternative Names
PENT; PNMTase
Function
Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (PubMed:20496117).
Other substrates include phenylethanolamine and octopamine (PubMed:8812853, PubMed:16363801, PubMed:16277617).
Also methylates normetanephrine (By similarity).
Biological Process
Catecholamine biosynthetic processTAS:Reactome
Epinephrine biosynthetic processIEA:UniProtKB-UniPathway
MethylationIEA:UniProtKB-KW
Cellular Location
Cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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