PNMT

The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene.
Full Name
PNMT
Function
Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (PubMed:20496117).
Other substrates include phenylethanolamine and octopamine (PubMed:8812853, PubMed:16363801, PubMed:16277617).
Also methylates normetanephrine (By similarity).
Biological Process
Catecholamine biosynthetic processTAS:Reactome
Epinephrine biosynthetic processIEA:UniProtKB-UniPathway
MethylationIEA:UniProtKB-KW
Cellular Location
Cytosol
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Anti-PNMT antibodies

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Mouse Anti-PNMT Recombinant Antibody (1B7) (CBMAB-P2264-YC)

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Target: PNMT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1B7
Application*: WB, IF, F
Datasheet SDS

Mouse Anti-PNMT Recombinant Antibody (3G4) (CBMAB-P2267-YC)

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Target: PNMT
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3G4
Application*: E, IP
Datasheet SDS

Mouse Anti-PNMT Recombinant Antibody (1C11) (CBMAB-P2265-YC)

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Target: PNMT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1C11
Application*: WB, E
Datasheet SDS

Mouse Anti-PNMT Recombinant Antibody (1B11) (CBMAB-P2263-YC)

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Target: PNMT
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1B11
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-PNMT Antibody (10BA11) (CBMAB-1495CQ)

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Target: PNMT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 10BA11
Application*: E, WB
Datasheet SDS

Mouse Anti-PNMT Antibody (10BA9) (CBMAB-1493CQ)

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Target: PNMT
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10BA9
Application*: E, WB
Datasheet SDS

Rabbit Anti-PNMT Recombinant Antibody (BA0338) (CBMAB-0665CQ)

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Target: PNMT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: BA0338
Application*: IF, WB
Datasheet SDS

Mouse Anti-PNMT Recombinant Antibody (1D2) (CBMAB-0664CQ)

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Target: PNMT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Dog, Monkey
Clone: 1D2
Application*: IF, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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