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PNMT

The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene.
Full Name
PNMT
Function
Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (PubMed:20496117).
Other substrates include phenylethanolamine and octopamine (PubMed:8812853, PubMed:16363801, PubMed:16277617).
Also methylates normetanephrine (By similarity).
Biological Process
Catecholamine biosynthetic processTAS:Reactome
Epinephrine biosynthetic processIEA:UniProtKB-UniPathway
MethylationIEA:UniProtKB-KW
Cellular Location
Cytosol

Anti-PNMT antibodies

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Rabbit Anti-PNMT Recombinant Antibody (BA0338) (CBMAB-0665CQ)

Datasheet SDS
Target: PNMT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: BA0338
Application*: IF, WB

Mouse Anti-PNMT Recombinant Antibody (1D2) (CBMAB-0664CQ)

Datasheet SDS
Target: PNMT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Dog, Monkey
Clone: 1D2
Application*: IF, P, WB

Mouse Anti-PNMT Antibody (10BA11) (CBMAB-1495CQ)

Datasheet SDS
Target: PNMT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 10BA11
Application*: E, WB

Mouse Anti-PNMT Antibody (10BA9) (CBMAB-1493CQ)

Datasheet SDS
Target: PNMT
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10BA9
Application*: E, WB

Mouse Anti-PNMT Recombinant Antibody (3G4) (CBMAB-P2267-YC)

Datasheet SDS
Target: PNMT
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3G4
Application*: E, IP

Mouse Anti-PNMT Recombinant Antibody (1C11) (CBMAB-P2265-YC)

Datasheet SDS
Target: PNMT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1C11
Application*: WB, E

Mouse Anti-PNMT Recombinant Antibody (1B7) (CBMAB-P2264-YC)

Datasheet SDS
Target: PNMT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1B7
Application*: WB, IF, F

Mouse Anti-PNMT Recombinant Antibody (1B11) (CBMAB-P2263-YC)

Datasheet SDS
Target: PNMT
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1B11
Application*: F, IF, P, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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