Mouse Anti-PPP1CB Recombinant Antibody (CBT1047) (V2LY-0625-LY3081)

Name: Mouse Anti-PPP1CB Recombinant Antibody (CBT1047)
SKU: V2LY-0625-LY3081
Rating: 5 (1 reviews)

See all PPP1CB antibodies

Compare Online Inquiry

Tested Data

Mouse Anti-PPP1CB Recombinant Antibody (CBT1047) (V2LY-0625-LY3081) in WB

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT1047

Application

Immunogen

Purified recombinant human PP1Beta protein fragments expressed in E.coli.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Chicken, Dog, Pig

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:1,000-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Tris-Glycine, Glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

protein phosphatase 1, catalytic subunit, beta isoform

Entrez Gene ID

5500

UniProt ID

P62140

Function

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).

Biological Process

Cell cycleIEA:UniProtKB-KW
Cell divisionIEA:UniProtKB-KW
Circadian regulation of gene expressionISS:UniProtKB
Entrainment of circadian clock by photoperiodISS:UniProtKB
Glycogen metabolic processIEA:UniProtKB-KW
MAPK cascadeTAS:Reactome
Protein dephosphorylationISS:UniProtKB
Regulation of cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of circadian rhythmManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Nucleus, nucleoplasm
Nucleus, nucleolus
Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.

Involvement in disease

Noonan syndrome-like disorder with loose anagen hair 2 (NSLH2):
A syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable, sparse, thin and slow-growing hair.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-PPP1CB Recombinant Antibody (CBT1047)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PPP1CB Recombinant Antibody (CBYC-P564) (CAT#: CBMAB-P2589-YC)

Mouse Anti-PPP1CB Recombinant Antibody (CBT4489) (CAT#: V2LY-0625-LY145)

Mouse Anti-PPP1CB Recombinant Antibody (8A7) (CAT#: CBMAB-P2588-YC)

Mouse Anti-PPP1CB Recombinant Antibody (CBT4519) (CAT#: V2LY-0625-LY153)

Mouse Anti-PPP1CB Recombinant Antibody (15B227) (CAT#: CBMAB-P2587-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry