Rabbit Anti-PRMT7 Recombinant Antibody (D1K6R) (CBMAB-CP2081-LY)

Name: Rabbit Anti-PRMT7 Recombinant Antibody (D1K6R)
SKU: CBMAB-CP2081-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Rabbit

Clone

D1K6R

Application

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val233 of human PRMT7 protein.

Specificity

Human, Mouse, Monkey, Cattle

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

PRMT7

Entrez Gene ID

Human	54496
Mouse	214572
Monkey	702853
Cattle	514202

UniProt ID

Human	Q9NVM4
Mouse	Q922X9
Monkey	F6WWP9
Cattle	A6QQV6

Function

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.

Biological Process

Cell differentiationIEA:UniProtKB-KW
DNA methylation involved in gamete generationISS:UniProtKB
Histone arginine methylationISS:UniProtKB
Histone methylationManual Assertion Based On ExperimentIDA:HGNC-UCL
Peptidyl-arginine methylationManual Assertion Based On ExperimentIDA:HGNC-UCL
Regulation of gene expression by genomic imprintingISS:UniProtKB
Regulation of protein binding1 PublicationIC:HGNC-UCL
Spliceosomal snRNP assemblyManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm, cytosol
Nucleus

Involvement in disease

Short stature, brachydactyly, impaired intellectual developmental, and seizures (SBIDDS):
An autosomal recessive disease characterized by developmental delay, learning disabilities, mild intellectual disability, delayed speech, and skeletal abnormalities. Skeletal features include short stature, brachydactyly, and short metacarpals and metatarsals.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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