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Rabbit Anti-PRMT7 Recombinant Antibody (D1K6R) (CBMAB-CP2081-LY)

The product is antibody recognizes PRMT7. The antibody D1K6R immunoassay techniques such as: WB.
See all PRMT7 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Monkey, Cattle
Clone
D1K6R
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val233 of human PRMT7 protein.
Specificity
Human, Mouse, Monkey, Cattle
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
PRMT7
Entrez Gene ID
Human54496
Mouse214572
Monkey702853
Cattle514202
UniProt ID
HumanQ9NVM4
MouseQ922X9
MonkeyF6WWP9
CattleA6QQV6
Function
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
Biological Process
Cell differentiationIEA:UniProtKB-KW
DNA methylation involved in gamete generationISS:UniProtKB
Histone arginine methylationISS:UniProtKB
Histone methylationManual Assertion Based On ExperimentIDA:HGNC-UCL
Peptidyl-arginine methylationManual Assertion Based On ExperimentIDA:HGNC-UCL
Regulation of gene expression by genomic imprintingISS:UniProtKB
Regulation of protein binding1 PublicationIC:HGNC-UCL
Spliceosomal snRNP assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm, cytosol
Nucleus
Involvement in disease
Short stature, brachydactyly, impaired intellectual developmental, and seizures (SBIDDS):
An autosomal recessive disease characterized by developmental delay, learning disabilities, mild intellectual disability, delayed speech, and skeletal abnormalities. Skeletal features include short stature, brachydactyly, and short metacarpals and metatarsals.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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