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Mouse Anti-PTP4A2 Recombinant Antibody (5B6F4) (CBMAB-P3404-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein tyrosine phosphatase type IVA, member 2. The antibody can be used for immunoassay techniques, such as ELISA, WB, IHC-P, IF, ICC, FC.
See all PTP4A2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5B6F4
Antibody Isotype
IgG2b
Application
ELISA, WB, IHC-P, IF, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human PTP4A2 expressed in E. coli
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS with 0.05% sodium azide and 0.5% protein stabilizer
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein tyrosine phosphatase type IVA, member 2
Introduction
PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity.
Entrez Gene ID
8073
UniProt ID
Q12974
Alternative Names
HH13; HH7-2; HU-PP-1; OV-1; PRL-2; PRL2; PTP4A; PTPCAAX2; ptp-IV1a; ptp-IV1b
Function
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.
Biological Process
Protein dephosphorylationIEA:InterPro
Cellular Location
Cell membrane
Early endosome
Cytoplasm
PTM
Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB. Unfarnesylated forms are redirected to the nucleus and cytosol.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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