Mouse Anti-RANBP1 Recombinant Antibody (35/RanBP1) (CBMAB-R1271-CN)

Name: Mouse Anti-RANBP1 Recombinant Antibody (35/RanBP1)
SKU: CBMAB-R1271-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

35/RanBP1

Application

WB, IF

Immunogen

Human RanBP1 aa. 28-163

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

0.25 mg/mL

More Infomation

Target

Full Name

RAN Binding Protein 1

Introduction

This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Entrez Gene ID

5902

UniProt ID

P43487

Alternative Names

RAN Binding Protein 1; Testis Secretory Sperm-Binding Protein Li 221n; Ran-Specific GTPase-Activating Protein; HpaII Tiny Fragments Locus 9A; Ran-Binding Protein 1; RanBP1; HTF9A;

Function

Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity).
Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264).
Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity).
Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426).
Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974).
Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7882974, PubMed:7616957).

Biological Process

Biological Process nucleocytoplasmic transportIEA:InterPro
Biological Process positive regulation of mitotic centrosome separationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

centrosome
cytoplasm
cytosol
nuclear envelope
nuclear pore
nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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